Effects of single-dose and co-supplementation of vitamin D and omega-3 on metabolic profile in women with polycystic ovary syndrome: An RCT

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Bahramian Hadis; Sherafatmanesh Saeed; Asadi Nasrin; Bakhshi Ali; Eftekhari Mohammad Hassan; Ekramzadeh Maryam

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Journal: International Journal of Reproductive BioMedicine Year:621 | Volume: | Issue: Page(s): 541-550

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Title

Effects of single-dose and co-supplementation of vitamin D and omega-3 on metabolic profile in women with polycystic ovary syndrome: An RCT

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Keywords

Polycystic ovary syndromeQ4

Vitamin DQ4

Omega-3 fatty acidQ4

InsulinQ4

Sex hormone-binding globulin.Q4

Abstract

Background: Polycystic ovary syndrome (PCOS) is a heterogeneous medical condition with a cluster of metabolic and endocrine disorders including dyslipidemia, Insulin resistance, and hyperandrogenism. Objective: The present study aimed to determine the effects of single-dose and co-supplementation of Vitamin D (vit D) and omega-3 (O3) on anthropometric and several biochemical factors in women with PCOS. Materials and Methods: In this double-blind, randomized clinical trial, 80 PCOS women referred to Shahid Motahhari Clinic, Shiraz, Iran, from April to October 2017 were studied in 4 groups (n = 20/each) for 8 wk. The placebo group received the placebo capsule (paraffin oil); 1 weekly and 2/daily; the vit D group received vit D (50,000 IU/weekly) + 2 placebo capsules daily, O3 group, 2, O3 capsules daily + 1 placebo capsule weekly, and vit D + O3 (50000 IU/weekly vit D + 2, O3 capsules daily). Before and after 8 wk of intervention, height, weight, body mass index, waist circumference, triglycerides, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting blood sugar, homeostasis model of Insulin resistance index, and sex hormone binding globulin were compared between groups. Results: The significant reduction was detected in serum triglyceride (p = 0.002), TC (p = 0.04), fasting blood sugar (p = 0.02), Insulin (p = 0.001), and homeostasis model of Insulin resistance index (p = 0.001) concentrations in all vit D, O3, and vit D + O3 supplemented groups compared to the placebo group. Furthermore, in comparison with the placebo group, a significant increase was observed in serum sex hormone binding globulin levels after vit D, O3, and vit D + O3 treatments. Nevertheless, no significant changes were observed in serum high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and anthropometric indices in all treated participants. Conclusion: The current study indicated that single dose and co-supplementation of vit D and O3 for 8 wk was associated with beneficial effects on serum triglyceride, TC, Insulin, and sex hormone binding globulin concentrations among women suffering from PCOS.

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APA: Copy

Bahramian, Hadis, Sherafatmanesh, Saeed, ASADI, NASRIN, BAKHSHI, ALI, EFTEKHARI, MOHAMMAD HASSAN, & EKRAMZADEH, MARYAM. (2023). Effects of single-dose and co-supplementation of vitamin D and omega-3 on metabolic profile in women with polycystic ovary syndrome: An RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 21(7), 541-550. SID. https://sid.ir/paper/1088765/en

Vancouver: Copy

Bahramian Hadis, Sherafatmanesh Saeed, ASADI NASRIN, BAKHSHI ALI, EFTEKHARI MOHAMMAD HASSAN, EKRAMZADEH MARYAM. Effects of single-dose and co-supplementation of vitamin D and omega-3 on metabolic profile in women with polycystic ovary syndrome: An RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2023;21(7):541-550. Available from: https://sid.ir/paper/1088765/en

IEEE: Copy

Hadis Bahramian, Saeed Sherafatmanesh, NASRIN ASADI, ALI BAKHSHI, MOHAMMAD HASSAN EFTEKHARI, and MARYAM EKRAMZADEH, “Effects of single-dose and co-supplementation of vitamin D and omega-3 on metabolic profile in women with polycystic ovary syndrome: An RCT,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 21, no. 7, pp. 541–550, 2023, [Online]. Available: https://sid.ir/paper/1088765/en

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