DETERMINATION OF THE CORRELATION BETWEEN HER-2 TUMOR FACTOR AND INVASION OF BREAST CANCER TO AXILLARY LYMPH NODES IN PATIENTS UNDERGOING MASTECTOMY IN CANCER INSTITUTE (2001-2003)

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SIRATI F.; YADEGARI K.

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Journal: Razi Journal of Medical Sciences Year:2005 | Volume:11 | Issue:43 Page(s): 781-788

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Title

DETERMINATION OF THE CORRELATION BETWEEN HER-2 TUMOR FACTOR AND INVASION OF BREAST CANCER TO AXILLARY LYMPH NODES IN PATIENTS UNDERGOING MASTECTOMY IN CANCER INSTITUTE (2001-2003)

Author(s)

SIRATI F. | YADEGARI K. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

HER-2Q4

TURNOR MARKERQ4

Abstract

BREAST CANCER is the most common site-specific cancer and is the second cause of mortality due to cancer in women. There are different prognostic factors including: axillary nodal status and tumor size (the most important factor), ER activity, PR, tumor grade and the type of histology. Other incompletely defined risk factors are: protease, catepstin, HER-2, etc. HER-2 is subtype 2 of EGF (Epidermal Growth Factor) receptor which may be presented in 10-34% of tumoral cells and is assumed to be a poor prognostic factor (probably because of high-power invasion of HER-2(+) tumors). The purpose of this study was to determine the correlation between HER-2 and invasion to axillary lymph nodes. For this purpose, all BREAST CANCERs operated between 2001-2003 in Imam Khomeini Cancer Institute were evaluated for size, age, menstrual status, ER, PR, P53,Her-2 and axillary lymph node status. Of 134 patients, 50 cases (37.3%) were T1 (Size<2cm), 62 cases (46.3%) T2 (Size=2-5cm), 18 cases (13.4%) T3 (Size>5cm) and 4 cases (3%) T4 (any size with skin or chest wall involvement). All T3 and T4 cases had axillary lymph node involvement. Thus, there was no correlation between HER-2 and lymph node status. In T1, of 32 HER-2(+) patients, 21(67.7%) were LN+ (Lymph-node positive) and 11(32.3%) patients were LN-(Lymph-node negative) and of 18 HER-2(-) patients, 3(16.3%) were LN+ and 15(83.7%) were LN-. In T2, of 37 HER-2(+) patients, 29(78.3%) were LN+ and 8(21.7%) were LN- and of 25 HER-2(-) patients, 7(28%) were LN+ and 18(72%) were LN-. T1 and T2 tumors had direct correlation between HER-2 and lymph node involvement, (Pv<0.05), and this correlation was independent of age, ER, PR, P53, histology and menstrual status.

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APA: Copy

SIRATI, F., & YADEGARI, K.. (2005). DETERMINATION OF THE CORRELATION BETWEEN HER-2 TUMOR FACTOR AND INVASION OF BREAST CANCER TO AXILLARY LYMPH NODES IN PATIENTS UNDERGOING MASTECTOMY IN CANCER INSTITUTE (2001-2003). RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 11(43), 781-788. SID. https://sid.ir/paper/10896/en

Vancouver: Copy

SIRATI F., YADEGARI K.. DETERMINATION OF THE CORRELATION BETWEEN HER-2 TUMOR FACTOR AND INVASION OF BREAST CANCER TO AXILLARY LYMPH NODES IN PATIENTS UNDERGOING MASTECTOMY IN CANCER INSTITUTE (2001-2003). RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2005;11(43):781-788. Available from: https://sid.ir/paper/10896/en

IEEE: Copy

F. SIRATI, and K. YADEGARI, “DETERMINATION OF THE CORRELATION BETWEEN HER-2 TUMOR FACTOR AND INVASION OF BREAST CANCER TO AXILLARY LYMPH NODES IN PATIENTS UNDERGOING MASTECTOMY IN CANCER INSTITUTE (2001-2003),” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 11, no. 43, pp. 781–788, 2005, [Online]. Available: https://sid.ir/paper/10896/en

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