مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

11
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

6
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Overcoming Drug Resistance in Breast Cancer Using Quercetin Nanodrugs

Pages

  292-301

Abstract

 Background & Objective: Breast Cancer is one of the most common cancers in the world. Treatment methods for this disease have been with poor results. In recent years, more attention has been paid to stem cells due to their cytotoxic properties. According to previous results, the effect of nanoQuercetin on Breast Cancer cells in this study was used concomitantly with Doxorubicin, which is a chemotherapy drug and in some patients has therapeutic resistance. Materials & Methods: The above study was performed on MCF7 and BT474 human Breast Cancer cells. Quercetin was synthesized, then different concentrations of 10, 20, 40, 80 and 160 of Quercetin and 1, 2. 5, 5 and 10 μ, g/ml of Doxorubicin were prepared and two cell lines were treated for 24 h. MTT test was used to determine cell viability and flow cytometry test was used to determine the extent of apoptosis in both cell lines. Results: The results showed that MCF7 and BT474 cells that were affected by Quercetin and Doxorubicin, increasing the concentration of Quercetin and Doxorubicin decreased the survival of both cell lines within 24 h. The LC50 concentration was calculated for both cells treated with nanoQuercetin 40 μ, g/ml and for Doxorubicin (0. 1 mg/mL). The results also showed that in both cell lines, an increase in cellular apoptosis occurred after incubation with Quercetin and then incubation with Doxorubicin. Conclusion: Comparison of Doxorubicin (DOX), Quercetin (QU) and Quercetin and Doxorubicin (QU-DOX) groups with controls shows that with the presence of Quercetin-Doxorubicin, it had a greater inhibitory effect on cancer cells.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Sorayabin Mobarhan, Fatemeh, TEIMOURI, MARYAM, & POOLADI, MEHDI. (2022). Overcoming Drug Resistance in Breast Cancer Using Quercetin Nanodrugs. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 12(3), 292-301. SID. https://sid.ir/paper/1089802/en

    Vancouver: Copy

    Sorayabin Mobarhan Fatemeh, TEIMOURI MARYAM, POOLADI MEHDI. Overcoming Drug Resistance in Breast Cancer Using Quercetin Nanodrugs. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2022;12(3):292-301. Available from: https://sid.ir/paper/1089802/en

    IEEE: Copy

    Fatemeh Sorayabin Mobarhan, MARYAM TEIMOURI, and MEHDI POOLADI, “Overcoming Drug Resistance in Breast Cancer Using Quercetin Nanodrugs,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 12, no. 3, pp. 292–301, 2022, [Online]. Available: https://sid.ir/paper/1089802/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button