C-Met Receptors Deficiency Was Involved in Absence Seizures Development inWAG/Rij Rats

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Amiri Mona; GHORBANI SAMIRA; Zavvari Fahime; HOSSEINI RAVANDI HASSAN; KARIMZADEH FARIBA

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Journal Paper

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Journal: Archives of Neuroscience Year:2023 | Volume:10 | Issue:1 Page(s): 0-0

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Title

C-Met Receptors Deficiency Was Involved in Absence Seizures Development inWAG/Rij Rats

Author(s)

Keywords

C-Met Receptors

Absence Epilepsy

Somatosensory Cortex

Hippocampus

Seizure

Abstract

Background: A variety of receptors may be involved in the pathogenesis of absence Seizures. The C-Met Receptors have a critical role in modulating the GABAergic interneurons and creating a balance between excitatory and inhibitory neurotransmission, sensorimotor gating, and normal synaptic plasticity. Objectives: This study aimed to assess the changes of the c-Met receptor during the appearance of absence attacks in the experimental model of Absence Epilepsy. Methods: A total of 48 animals were divided into four groups of two-and six-month-oldWAG/Rij and Wistar rats. EpilepticWAG/Rij rats showingSWPin electrocorticogram (ECoG) were included in the epileptic group. The two-month-oldWAG/Rij rats as well as twoand six-month-old Wistar rats not exhibiting SWP in ECoG were selected as the non-epileptic. Gene (RT-PCR) and protein expression (western blotting) of C-Met Receptors as well as c-Met protein distribution (immunohistochemistry) in the Somatosensory Cortex and Hippocampus were assessed during Seizure development of the absence attacks. Results: According to the study findings, a lower c-Met gene and protein expression, as well as a lower protein distribution, were observed in the Hippocampus (P < 0. 001, P < 0. 05, and P < 0. 001, respectively) and cortex (P < 0. 01, P < 0. 001 and P < 0. 001, respectively) of the two-month-old WAG/Rij rats compared to the same-age Wistar rats. Moreover, the data revealed a reduction of hippocampal and cortical c-Met protein expression (P < 0. 001, for both) in six-month-old WAG/Rij rats compared to two-monthold ones. Six-month-oldWAG/Rij rats had a lower cortical c-Met gene (P < 0. 05) and protein expression (P < 0. 001) as well as lower hippocampal and cortical protein distribution (P < 0. 05 and P < 0. 001) than the same-age Wistar rats. Conclusions: In sum, the c-Met receptor was found to play a significant role in the development of Absence Epilepsy. This receptor, therefore, may have been considered as an effective goal for absence Seizure inhibition.

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APA: Copy

Amiri, Mona, GHORBANI, SAMIRA, Zavvari, Fahime, HOSSEINI RAVANDI, HASSAN, & KARIMZADEH, FARIBA. (2023). C-Met Receptors Deficiency Was Involved in Absence Seizures Development inWAG/Rij Rats. ARCHIVES OF NEUROSCIENCE, 10(1), 0-0. SID. https://sid.ir/paper/1091257/en

Vancouver: Copy

Amiri Mona, GHORBANI SAMIRA, Zavvari Fahime, HOSSEINI RAVANDI HASSAN, KARIMZADEH FARIBA. C-Met Receptors Deficiency Was Involved in Absence Seizures Development inWAG/Rij Rats. ARCHIVES OF NEUROSCIENCE[Internet]. 2023;10(1):0-0. Available from: https://sid.ir/paper/1091257/en

IEEE: Copy

Mona Amiri, SAMIRA GHORBANI, Fahime Zavvari, HASSAN HOSSEINI RAVANDI, and FARIBA KARIMZADEH, “C-Met Receptors Deficiency Was Involved in Absence Seizures Development inWAG/Rij Rats,” ARCHIVES OF NEUROSCIENCE, vol. 10, no. 1, pp. 0–0, 2023, [Online]. Available: https://sid.ir/paper/1091257/en

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