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Information Journal Paper

Title

Serum Level of GDNF is Associated with Adherence to Methadone Maintenance Treatment

Pages

  0-0

Abstract

 Background: Preclinical studies have shown that neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF), are involved in the modulation of biochemical and behavioral adaptations to substance use. Methods: We studied the impact of GDNF and BDNF serum levels on adherence to methadone maintenance treatment (MMT) through cross-sectional research. Participants were clients on MMT (43 males), subjects in remission from opioid use disorder (12 males), and healthy controls (20 males). Adherence and non-adherence to treatment were assessed by the detection of illicit opioids in random urinalysis. Results: Using t-tests for independent groups and analysis of variance (ANOVA), GDNF serum levels in the adherent patients toMMT were found to be significantly higher than in the non-adherent patients. BDNF serum levels were not different between adherent and non-adherent patients. Conclusions: Our results suggest the involvement of GDNF as a biological factor in adherence to MMT.

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    APA: Copy

    Afghani, Aida, RAZAGHI, EMRAN M., Rastgoo Sisakht, Reza, FARHOUDIAN, ALI, & VOUSOOGHI, NASIM. (2023). Serum Level of GDNF is Associated with Adherence to Methadone Maintenance Treatment. ARCHIVES OF NEUROSCIENCE, 10(3), 0-0. SID. https://sid.ir/paper/1091911/en

    Vancouver: Copy

    Afghani Aida, RAZAGHI EMRAN M., Rastgoo Sisakht Reza, FARHOUDIAN ALI, VOUSOOGHI NASIM. Serum Level of GDNF is Associated with Adherence to Methadone Maintenance Treatment. ARCHIVES OF NEUROSCIENCE[Internet]. 2023;10(3):0-0. Available from: https://sid.ir/paper/1091911/en

    IEEE: Copy

    Aida Afghani, EMRAN M. RAZAGHI, Reza Rastgoo Sisakht, ALI FARHOUDIAN, and NASIM VOUSOOGHI, “Serum Level of GDNF is Associated with Adherence to Methadone Maintenance Treatment,” ARCHIVES OF NEUROSCIENCE, vol. 10, no. 3, pp. 0–0, 2023, [Online]. Available: https://sid.ir/paper/1091911/en

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