Investigation of an Increase in the Expression of the Mir146a Gene in The Hippocampus and a Decrease in the Levels of Blood Sugar, Insulin, and Insulin Resistance in Elderly Diabetic Rats after a Period of High-Intensity Interval Training

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Shamshadi Bahman; ASKARI ROYA; Rezaei Rasul; HAGHIGHI AMIR HOSSEIN

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Journal: JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES Year:2023 | Volume:14 | Issue:4 Page(s): 75-86

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Information Journal Paper

Title

Investigation of an Increase in the Expression of the Mir146a Gene in The Hippocampus and a Decrease in the Levels of Blood Sugar, Insulin, and Insulin Resistance in Elderly Diabetic Rats after a Period of High-Intensity Interval Training

Author(s)

Shamshadi Bahman | ASKARI ROYA | Rezaei Rasul | HAGHIGHI AMIR HOSSEIN | Issue Writer Certificate

Keywords

Aging

Diabetes

Hippocampus

Mir146a

Abstract

Introduction: MicroRNAs have been reported as potentially valuable biomarkers for various diseases, including Diabetes, heart diseases, neurological diseases, and agerelated diseases. The present study aimed to investigate the effect of 8 weeks of intense intermittent exercise on the expression of Mir146a, blood sugar, insulin, and insulin resistance in the Hippocampus of aged diabetic male rats. Method: This study was performed on 40 male Wistar rats aged 18-21 months with an average weight of 280±, 20 g. After becoming diabetic through streptozotocin solution, they were randomly divided into 4 groups, including 1) healthy high-intensity interval training (HIIT) exercise, 2) healthy control, 3) diabetic HIIT exercise, and 4) diabetic control. It should be mentioned that each group included 10 rats. The exercise groups exercised 5 days a week according to the HIIT programs for 8 weeks. The collected data were analyzed using GraphPad Prism software (version 8) at a significance level of P<0. 05. Results: The results showed that 8 weeks of HIIT exercise increased the expression of Mir146a in both of the exercise groups, compared to the diabetic control group (P<0. 001). Moreover, the blood sugar, insulin, and insulin resistance levels significantly decreased in the diabetic exercise, healthy HIIT exercise, and healthy control groups, compared to the diabetic control group (P<0. 001). Conclusion: It can be concluded that 8 weeks of HIIT training, which increased the expression of Mir146a, can reduce neuronal destruction in the Hippocampus region. Moreover, it can be used as a suitable non-therapeutic mechanism for diabetics to prevent or reduce damage in this brain region that is related to cognitive abilities.

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APA: Copy

Shamshadi, Bahman, ASKARI, ROYA, Rezaei, Rasul, & HAGHIGHI, AMIR HOSSEIN. (2023). Investigation of an Increase in the Expression of the Mir146a Gene in The Hippocampus and a Decrease in the Levels of Blood Sugar, Insulin, and Insulin Resistance in Elderly Diabetic Rats after a Period of High-Intensity Interval Training. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, 14(4 ), 75-86. SID. https://sid.ir/paper/1092194/en

Vancouver: Copy

Shamshadi Bahman, ASKARI ROYA, Rezaei Rasul, HAGHIGHI AMIR HOSSEIN. Investigation of an Increase in the Expression of the Mir146a Gene in The Hippocampus and a Decrease in the Levels of Blood Sugar, Insulin, and Insulin Resistance in Elderly Diabetic Rats after a Period of High-Intensity Interval Training. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2023;14(4 ):75-86. Available from: https://sid.ir/paper/1092194/en

IEEE: Copy

Bahman Shamshadi, ROYA ASKARI, Rasul Rezaei, and AMIR HOSSEIN HAGHIGHI, “Investigation of an Increase in the Expression of the Mir146a Gene in The Hippocampus and a Decrease in the Levels of Blood Sugar, Insulin, and Insulin Resistance in Elderly Diabetic Rats after a Period of High-Intensity Interval Training,” JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 4 , pp. 75–86, 2023, [Online]. Available: https://sid.ir/paper/1092194/en

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