THE SYNERGISTIC EFFECT OF EIGHT WEEKS HIGH-INTENSITY INTERVAL TRAINING AND RESVERATROL CONSUMPTION ON IL-10 AND TNF-Α IN DIABETIC MALE RATS

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HOSSEINI MASOUMEH; HOSSEINI MARYAM

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Journal: Iranian Journal of Diabetes and Metabolism Year:2020 | Volume:19 | Issue:3 Page(s): 134-142

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Title

THE SYNERGISTIC EFFECT OF EIGHT WEEKS HIGH-INTENSITY INTERVAL TRAINING AND RESVERATROL CONSUMPTION ON IL-10 AND TNF-Α IN DIABETIC MALE RATS

Author(s)

HOSSEINI MASOUMEH | HOSSEINI MARYAM | Issue Writer Certificate

Keywords

ResveratrolQ2

IL-10Q2

Interval trainingQ1

Diabetic ratQ2

Abstract

Background: The proinflammatory cytokines of tumor necrosis factor alpha TNF-α and anti-inflammatory interleukin-10 have important roles in inducing and preventing systemic inflammation, respectively. The purpose of this study was to the synergistic effect of High-Intensity Interval training and Resveratrol consumption on IL-10 and TNF-α in Diabetic rats. Methods: In this experimental study, 32 Diabetic rats 225± 10 g based on Cohen's sample size estimation table diabetic with combination of high-fat diet and streptozotocin (STZ) injection, were randomly divided into four groups: control(C), supplement(M), training (T)and training + supplement(TM). The training groups were exposed to high-intensity Interval training with an intensity of 90 to 100% VO2max for 8 weeks, 5 sessions per week, each session for 18 minutes. The supplement groups received 10 mg / kg of Resveratrol daily for eight weeks, three times a week by gavage. Blood samples were taken 48 hours after the last training session. Data were analyzed using one-way analysis of variance and SPSS software version 24 (ANOVA). Results: Results showed that IL-10 increased in the experimental groups but was not significant (P=0. 109). TNF-α levels decreased in the TM group, whereas it increased in the T and M groups, which was significant compared to the TM group (P=. 000). Fasting glucose, insulin and insulin resistance index decreased significantly in experimental groups (P=. 000). Conclusion: Eight weeks of high-intensity Interval training plus Resveratrol can have a positive effect on inflammation and insulin resistance by increasing IL-10 and decreasing TNF-α .

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APA: Copy

HOSSEINI, MASOUMEH, & HOSSEINI, MARYAM. (2020). THE SYNERGISTIC EFFECT OF EIGHT WEEKS HIGH-INTENSITY INTERVAL TRAINING AND RESVERATROL CONSUMPTION ON IL-10 AND TNF-Α IN DIABETIC MALE RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 19(3 ), 134-142. SID. https://sid.ir/paper/413816/en

Vancouver: Copy

HOSSEINI MASOUMEH, HOSSEINI MARYAM. THE SYNERGISTIC EFFECT OF EIGHT WEEKS HIGH-INTENSITY INTERVAL TRAINING AND RESVERATROL CONSUMPTION ON IL-10 AND TNF-Α IN DIABETIC MALE RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2020;19(3 ):134-142. Available from: https://sid.ir/paper/413816/en

IEEE: Copy

MASOUMEH HOSSEINI, and MARYAM HOSSEINI, “THE SYNERGISTIC EFFECT OF EIGHT WEEKS HIGH-INTENSITY INTERVAL TRAINING AND RESVERATROL CONSUMPTION ON IL-10 AND TNF-Α IN DIABETIC MALE RATS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 19, no. 3 , pp. 134–142, 2020, [Online]. Available: https://sid.ir/paper/413816/en

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