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Information Journal Paper

Title

Comparative Evaluation of Melatonin as an Alternative Therapy in Tinnitus: A Double-Blind, Placebo-Controlled Randomized Trial

Pages

  0-0

Abstract

 Background: Tinnitus is an auditory perception that is described as a perception of noise without any external acoustic stimulant. Tinnitus causes many problems including sleep disturbances and difficulty in concentrating for patients. Aim: In this trial we evaluated Melatonin as an alternative therapy in Tinnitus. Methods: In this clinical trial, Tinnitus patients (n = 90) were randomly assigned to 12 weeks of double-blind treatment with Melatonin (n = 30) at a fixed-dose (3 mg once daily), Sertraline (n = 30) at a fixed dose (50 mg once daily) and placebo (n = 30) once daily. The treatment outcomes were measured using THI (Tinnitus Handicap Inventory), Tinnitus loudness score, and Tinnitus awareness score after 3 months. Results: The baseline assessment with THI (Tinnitus Handicap Inventory) showed no significant difference in THI score between groups before treatment (p-value = 0. 38). The mean THI score shows a significant decrease in both Melatonin and Sertraline groups (p-value < 0. 03). Overall, a mean of 20% decrease in Tinnitus loudness score and a 2-fold decrease in Tinnitus awareness score was seen in the Melatonin group. In contrast, a mean of 2% decrease in Tinnitus loudness score and 25% decrease in Tinnitus awareness score was seen in the Sertraline group. Conclusion: Both Melatonin and Sertraline reduce Tinnitus loudness score and Tinnitus awareness score within 12 weeks in primary care, but Melatonin showed a more significant outcome. Our findings support the prescription of Melatonin in Tinnitus management.

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    APA: Copy

    Rahimipour, Niloufar. (2022). Comparative Evaluation of Melatonin as an Alternative Therapy in Tinnitus: A Double-Blind, Placebo-Controlled Randomized Trial. JOURNAL OF OTORHINOLARYNGOLOGY AND FACIAL PLASTIC SURGERY, 8(1), 0-0. SID. https://sid.ir/paper/1094705/en

    Vancouver: Copy

    Rahimipour Niloufar. Comparative Evaluation of Melatonin as an Alternative Therapy in Tinnitus: A Double-Blind, Placebo-Controlled Randomized Trial. JOURNAL OF OTORHINOLARYNGOLOGY AND FACIAL PLASTIC SURGERY[Internet]. 2022;8(1):0-0. Available from: https://sid.ir/paper/1094705/en

    IEEE: Copy

    Niloufar Rahimipour, “Comparative Evaluation of Melatonin as an Alternative Therapy in Tinnitus: A Double-Blind, Placebo-Controlled Randomized Trial,” JOURNAL OF OTORHINOLARYNGOLOGY AND FACIAL PLASTIC SURGERY, vol. 8, no. 1, pp. 0–0, 2022, [Online]. Available: https://sid.ir/paper/1094705/en

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