Synthesis and Characterization of Deferasirox PLGA Nanoparticles and Investigation of Toxicity in Cell Model

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MOHAMMADI HAMIDREZA; AKHTARI JAVAD; Assadpour Sara; Kamali Mitra; EBRAHIMNEJAD PEDRAM

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Journal Paper

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Journal: Journal of Mazandaran University of Medical Sciences Year:2022 | Volume:32 | Issue:214 Page(s): 65-76

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Title

Synthesis and Characterization of Deferasirox PLGA Nanoparticles and Investigation of Toxicity in Cell Model

Author(s)

Keywords

cancer cell

deferasirox nanoparticles

cytotoxicity

MTT

Abstract

Background and purpose: Cancer is one of the causes of mortality worldwide. Evidence suggests that iron depletion by a chelator agent suppresses the development of some cancer cells. Deferasirox is shown to have anticancer properties. This research aims to synthesize and evaluate the effects of deferasirox nanoparticles on human breast cancer cells (SKBR3) and mouse breast cancer cells (4T1) compared with the drug form. Materials and methods: deferasirox nanoparticles were synthesized by Poly lactic-co-glycolic acid (PLGA) moiety with emulsion formation and solvent evaporation. cytotoxicity was evaluated using the MTT assay and their 50% inhibitory concentration (IC50) were assessed in SKBR3 and 4T1. Results: Findings showed that IC50 of nano-deferasirox for SKBR3 and 4T1 were 9. 09±, 0. 011 µ, g/ml and 6. 6±, 0. 032 µ, g/ml, respectively and the IC50 of the deferasirox drug form for SKBR3 and 4T1 IC50 were 21. 07±, 0. 003 µ, g/ml and 11. 08±, 0. 013 µ, g/ml, respectively. Conclusion: The anticancer effects of deferasirox were confirmed on the cell lines, and the improved properties and efficacy were also confirmed on two cancer cell lines. Nanoparticle delivery systems improve absorption and drug properties and increase the effectiveness of the drug.

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APA: Copy

MOHAMMADI, HAMIDREZA, AKHTARI, JAVAD, Assadpour, Sara, Kamali, Mitra, & EBRAHIMNEJAD, PEDRAM. (2022). Synthesis and Characterization of Deferasirox PLGA Nanoparticles and Investigation of Toxicity in Cell Model. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 32(214 ), 65-76. SID. https://sid.ir/paper/1095546/en

Vancouver: Copy

MOHAMMADI HAMIDREZA, AKHTARI JAVAD, Assadpour Sara, Kamali Mitra, EBRAHIMNEJAD PEDRAM. Synthesis and Characterization of Deferasirox PLGA Nanoparticles and Investigation of Toxicity in Cell Model. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2022;32(214 ):65-76. Available from: https://sid.ir/paper/1095546/en

IEEE: Copy

HAMIDREZA MOHAMMADI, JAVAD AKHTARI, Sara Assadpour, Mitra Kamali, and PEDRAM EBRAHIMNEJAD, “Synthesis and Characterization of Deferasirox PLGA Nanoparticles and Investigation of Toxicity in Cell Model,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 32, no. 214 , pp. 65–76, 2022, [Online]. Available: https://sid.ir/paper/1095546/en

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