Apoptosis Effects of Oxalis Corniculata L. Extract on Human MCF-7 Breast Cancer Cell Line

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Gholipour Amir Reza; JAFARI LEILA; RAMEZANPOUR MAHSA; Evazalipour Mehdi; Chavoshi Maral; YOUSEFBEYK FATEMEH; Kargar Moghaddam Saghi Jani; YEKTA KOOSHALI MOHAMMAD HOSSEIN; Ramezanpour Nahid; DAEI PUYAN; GHASEMI SAEED; HAMIDI MASOUD

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Journal: Galen Medical Journal Year:2022 | Volume:11 | Issue:1 Page(s): 0-0

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Title

Apoptosis Effects of Oxalis Corniculata L. Extract on Human MCF-7 Breast Cancer Cell Line

Author(s)

Keywords

Apoptosis

MCF-7

Breast Cancer

Oxalis Corniculate

Bax

p53

Bcl-2

Abstract

Background: Recently, the non-toxic properties of natural plant products have gained more focus as anticancer agents. Therefore, this study aimed to assess the Apoptosis effects of the ethanolic extract of Oxalis corniculata on the MCF-7 Breast Cancer cell line. Materials and Methods: In this experimental study, aerial parts of O. corniculata were collected in Lahijan city (Iran), and after confirmation, they were dried and extracted with ethanol for 24 h. Then, the total phenolic and flavonoid contents of the extract were measured. The 2, 2-diphenyl-1-picrylhydrazyl radical scavenging assay was used to measure the antioxidant properties of the extract. Selected cell lines (MCF-7 and human dermal fibroblast) were cultured in 6-wells dishes (1×106 cells/well). After 72 h of treating the extract, cytotoxicity was assessed using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) assay. The expression of apoptotic genes (such as p53, Bcl-2, Bax, and CD95) was studied by real-time polymerase chain reaction (PCR). Results: The extract's total phenolic content was 31. 30±, 02 μ, g of gallic acid equivalents/mg of dry extract, and the total flavonoid content was 49. 61±, 04 μ, g of quercetin as equivalents/mg of extract. The antioxidant activity of O. corniculata was measured at the dose of 619. 2 μ, g/μ, l, indicating that it decreases cancer cell viability and enhances Apoptosis. Within the half maximal inhibitory concentrations, real-time PCR revealed substantial increases in p53 (P<0. 001), CD95 (P<0. 05), and Bcl-2 expression (P<0. 05) in MCF-7 cells treated with O. corniculata. Conclusion: This study suggests that O. corniculata may cause Apoptosis by oxidative stress in cancer cells.

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APA: Copy

Gholipour, Amir Reza, JAFARI, LEILA, RAMEZANPOUR, MAHSA, Evazalipour, Mehdi, Chavoshi, Maral, YOUSEFBEYK, FATEMEH, Kargar Moghaddam, Saghi Jani, YEKTA KOOSHALI, MOHAMMAD HOSSEIN, Ramezanpour, Nahid, DAEI, PUYAN, GHASEMI, SAEED, & HAMIDI, MASOUD. (2022). Apoptosis Effects of Oxalis Corniculata L. Extract on Human MCF-7 Breast Cancer Cell Line. GALEN MEDICAL JOURNAL, 11(1), 0-0. SID. https://sid.ir/paper/1095676/en

Vancouver: Copy

Gholipour Amir Reza, JAFARI LEILA, RAMEZANPOUR MAHSA, Evazalipour Mehdi, Chavoshi Maral, YOUSEFBEYK FATEMEH, Kargar Moghaddam Saghi Jani, YEKTA KOOSHALI MOHAMMAD HOSSEIN, Ramezanpour Nahid, DAEI PUYAN, GHASEMI SAEED, HAMIDI MASOUD. Apoptosis Effects of Oxalis Corniculata L. Extract on Human MCF-7 Breast Cancer Cell Line. GALEN MEDICAL JOURNAL[Internet]. 2022;11(1):0-0. Available from: https://sid.ir/paper/1095676/en

IEEE: Copy

Amir Reza Gholipour, LEILA JAFARI, MAHSA RAMEZANPOUR, Mehdi Evazalipour, Maral Chavoshi, FATEMEH YOUSEFBEYK, Saghi Jani Kargar Moghaddam, MOHAMMAD HOSSEIN YEKTA KOOSHALI, Nahid Ramezanpour, PUYAN DAEI, SAEED GHASEMI, and MASOUD HAMIDI, “Apoptosis Effects of Oxalis Corniculata L. Extract on Human MCF-7 Breast Cancer Cell Line,” GALEN MEDICAL JOURNAL, vol. 11, no. 1, pp. 0–0, 2022, [Online]. Available: https://sid.ir/paper/1095676/en

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