THE EFFECT OF CADMIUM CHLORIDE ON KIDNEY GLOMERULI OF RAT EMBRYO AND NEONATE

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MAHDIZADEH M.; MOULAEI F.; NOUR MOHAMMADZADEH F.; NOUBAKHT M.; PARIVAR KAZEM

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Journal: Razi Journal of Medical Sciences Year:2005 | Volume:11 | Issue:44 (SPECIAL ISSUE 2) Page(s): 1035-1042

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Title

THE EFFECT OF CADMIUM CHLORIDE ON KIDNEY GLOMERULI OF RAT EMBRYO AND NEONATE

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Keywords

GLOMERULUSQ3

RATQ2

CADMIUM CHLORIDEQ2

EMBRYOQ3

Abstract

Cadmium (Cd) is an environmental contaminant and an important toxic chemical with teratogenic and EMBRYOtoxic effect. Chronic human exposure to Cd will result in kidney injury. The present investigation was conducted to study the effects of CADMIUM CHLORIDE (CdCI2) on structural changes in RAT EMBRYO and neonate glomeruli. Thirty female Sprauge-dawley RATs with mean weight of 180-240 gr were used in this study. They were classified into 6 quintet groups. On the 9th day of pregnancy, 2mgjkg CADMIUM CHLORIDE was injected intra peritoneally in right lower quadrant of abdomen in groups I & III, 4mgjkg in groups IIl & IV and only 1mljkg Normal Saline in groups V &VI. Left kidneys were removed in groups I, II &V on the 21st day of pregnancy and in groups III, IV and VI 3 days after the birth. Specimens were fixed with bouin's solution and stained with H&E for microscopic changes examination including: glomeruli number, diameter and morphology. The results showed that prenatal exposure to CdC12 can induce significant changes in the histometry and differentiation of glomeruli. Such changes appear to be restricted to the late prenatal and early postnatal period and to occur in the absence of other overt signs of toxicity.

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APA: Copy

MAHDIZADEH, M., MOULAEI, F., NOUR MOHAMMADZADEH, F., NOUBAKHT, M., & PARIVAR, KAZEM. (2005). THE EFFECT OF CADMIUM CHLORIDE ON KIDNEY GLOMERULI OF RAT EMBRYO AND NEONATE. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 11(44 (SPECIAL ISSUE 2)), 1035-1042. SID. https://sid.ir/paper/10976/en

Vancouver: Copy

MAHDIZADEH M., MOULAEI F., NOUR MOHAMMADZADEH F., NOUBAKHT M., PARIVAR KAZEM. THE EFFECT OF CADMIUM CHLORIDE ON KIDNEY GLOMERULI OF RAT EMBRYO AND NEONATE. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2005;11(44 (SPECIAL ISSUE 2)):1035-1042. Available from: https://sid.ir/paper/10976/en

IEEE: Copy

M. MAHDIZADEH, F. MOULAEI, F. NOUR MOHAMMADZADEH, M. NOUBAKHT, and KAZEM PARIVAR, “THE EFFECT OF CADMIUM CHLORIDE ON KIDNEY GLOMERULI OF RAT EMBRYO AND NEONATE,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 11, no. 44 (SPECIAL ISSUE 2), pp. 1035–1042, 2005, [Online]. Available: https://sid.ir/paper/10976/en

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