EFFECTS OF CADMIUM CHLORIDE ON CRANIAL PART OF NEURAL TUBE DEVELOPMENT IN MOUSE FETUSES

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KARIMIPOUR M.; ARABI Z.; NOUBAKHT M.; JAMEI B.; PIRAVY T.

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Journal: Studies in Medical Sciences Year:2006 | Volume:17 | Issue:1 Page(s): 36-40

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Title

EFFECTS OF CADMIUM CHLORIDE ON CRANIAL PART OF NEURAL TUBE DEVELOPMENT IN MOUSE FETUSES

Author(s)

Keywords

CADMIUM CHLORIDEQ4

MOUSEQ3

TERATOGENQ3

CENTRAL NERVOUS SYSTEMQ2

Abstract

Background & Aims: CADMIUM CHLORIDE is an essential component of industrial and non-industrial materials such as foods, water and cigarettes. Reports have shown the TERATOGENic effects of cadmium, thus the present study was performed with the aim of determining the effects of cadmium on the CENTRAL NERVOUS SYSTEM in MOUSE fetuses.Materials & Methods: In this experimental study, 30 female mice were included. Samples were divided in three groups of control, experimental I and n. Experimental groups have received CADMIUM CHLORIDE with dosage of 3 mg/kg and 5 mg/kg intraperitonealy on the 9th day of pregnancy, respectively. The control group received distilled the water. On the 15th day of pregnancy, the mice were killed by ether and their fetuses were removed, then weight and height of the fetuses were measured and then was kept in fixative. Finally, specimens were prepared and stained by H&E.Results: The Weight and height of embryos in experimental groups were significantly lower than the control group. Diameter of third ventricle and cerebral aqueduct in experimental groups significantly were increased compared to the control group. Furthermore lateral and the fourth ventricles thickness in experimental groups were significantly decreased. (p<0.001).Discussion: The results show that prenatal exposure to CADMIUM CHLORIDE can induce significantly changes in CNS and growth of mice fetuses.

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APA: Copy

KARIMIPOUR, M., ARABI, Z., NOUBAKHT, M., JAMEI, B., & PIRAVY, T.. (2006). EFFECTS OF CADMIUM CHLORIDE ON CRANIAL PART OF NEURAL TUBE DEVELOPMENT IN MOUSE FETUSES. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 17(1), 36-40. SID. https://sid.ir/paper/63887/en

Vancouver: Copy

KARIMIPOUR M., ARABI Z., NOUBAKHT M., JAMEI B., PIRAVY T.. EFFECTS OF CADMIUM CHLORIDE ON CRANIAL PART OF NEURAL TUBE DEVELOPMENT IN MOUSE FETUSES. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2006;17(1):36-40. Available from: https://sid.ir/paper/63887/en

IEEE: Copy

M. KARIMIPOUR, Z. ARABI, M. NOUBAKHT, B. JAMEI, and T. PIRAVY, “EFFECTS OF CADMIUM CHLORIDE ON CRANIAL PART OF NEURAL TUBE DEVELOPMENT IN MOUSE FETUSES,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 17, no. 1, pp. 36–40, 2006, [Online]. Available: https://sid.ir/paper/63887/en

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