مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Phosphodiesterase 5 Inhibitors as Therapeutics for Cardiovascular Diseases: A Brief Review

Pages

  870-879

Abstract

 Background: Three selective and most used inhibitors of PDE-5-sildenafil, vardenafil and tadalafil-have been successfully used for the treatment of erectile dysfunction. Erectile dysfunction and cardiovascular dis-eases might be considered as two dissimilar clinical signs of the identical systemic disease. PDE-5 inhibitors can through different models and mechanisms induce vasodilation, decrease apoptosis and cell proliferation, and they are widely present in various tissues that make them promising targets in a range of Cardiovascular diseases. Methods: PubMed was explored to identify papers published from 1990-2019, presenting data for the most used PDE-5 inhibitors (sildenafil, tadalafil or vardenafil) in treatment of Cardiovascular diseases. Results: This article analyses the therapeutic potentials of PDE-5 inhibitors in Cardiovascular diseases and discusses mechanisms, possible risks and limitations. Comparable to earlier studies, newer studies suggest car-dioprotective effects of PDE-5 inhibitors, which include different models and mechanisms and do not indi-cate an increased rate of significant cardiovascular adverse reactions. Dissimilarity in the pharmacokinetics and pharmacodynamics of PDE-5 inhibitors are significant to their risk-benefit profile and clinical use. Some of the studies suggesting infarct size reduction after PDE-5 inhibition described the especially close dose-effect relation, other studies dosage adaptation in drug-drug interactions. Conclusion: PDE-5 inhibitors indicate the encouraging useful effects by ischemia/reperfusion injury, myocar-dial infarction, cardiac hypertrophy, cardiomyopathy and systolic and diastolic congestive heart failure. There-fore, this and similar reviews can help for additional clinical targeting in the therapy of Cardiovascular diseases.

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    APA: Copy

    Corbic, Milena, Sretenovic, Jasmina, ZIVKOVIC, VLADIMIR, & JAKOVLJEVIC, VLADIMIR. (2023). Phosphodiesterase 5 Inhibitors as Therapeutics for Cardiovascular Diseases: A Brief Review. IRANIAN JOURNAL OF PUBLIC HEALTH, 52(5), 870-879. SID. https://sid.ir/paper/1098198/en

    Vancouver: Copy

    Corbic Milena, Sretenovic Jasmina, ZIVKOVIC VLADIMIR, JAKOVLJEVIC VLADIMIR. Phosphodiesterase 5 Inhibitors as Therapeutics for Cardiovascular Diseases: A Brief Review. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2023;52(5):870-879. Available from: https://sid.ir/paper/1098198/en

    IEEE: Copy

    Milena Corbic, Jasmina Sretenovic, VLADIMIR ZIVKOVIC, and VLADIMIR JAKOVLJEVIC, “Phosphodiesterase 5 Inhibitors as Therapeutics for Cardiovascular Diseases: A Brief Review,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 52, no. 5, pp. 870–879, 2023, [Online]. Available: https://sid.ir/paper/1098198/en

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