SARS-CoV-2 Viral Load in PregnantWomen and Association with Maternal Disease Severity and Neonatal Outcomes

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Yasa Beril; KARABULUT NURAN; Ilker Uslu Sait; Memur Seyma; Yavuzcan Ozturk Dilek; Bagci Onur; Sema Can Buker Halime; Polat Ibrahim; CETINKAYA MERIH

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Journal Paper

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Journal: Iranian Journal of Pediatrics Year:2023 | Volume:33 | Issue:1 Page(s): 0-0

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Title

SARS-CoV-2 Viral Load in PregnantWomen and Association with Maternal Disease Severity and Neonatal Outcomes

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Keywords

SARS-CoV-2 InfectionQ4

PregnancyQ4

Viral LoadQ4

Disease SeverityQ4

Neonatal OutcomesQ4

Abstract

Background: The outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) created unexpected impacts worldwide. Objectives: This study aimed to examine the association of SARS-CoV-2 Viral Load in pregnantwomenwith maternal Disease Severity and Neonatal Outcomes. Methods: In this retrospective cohort study, 55 pregnantwomeninfected with SARS-CoV-2 and their newborn infants were included. The association between maternal Viral Load (tested by cycle threshold) and maternal Disease Severity/Neonatal Outcomes was examined. Results: Infants had a median gestational age of 38 (29-41) weeks and birth weight of 3200 (630-4570) grams. The median Ct value of pregnant women was 30 (20-37). No significant difference was detected among mild, moderate or severely ill pregnant women in terms of median Ct values (30, 28. 5, and 30, respectively,P > 0. 05). The median Ct value of pregnant women who gave preterm delivery was similar to those who had term delivery [30 (21-36) vs. 30 (25-35),P > 0. 05]. The median Ct values were similar among pregnant women who died or survived [32. 5 (30-34) vs. 30 (21-36),P > 0. 05]. Preterm delivery rates and overall mortality were not associated with SARS-CoV-2 RT-qPCR Ct values, (r = 0. 04, P > 0. 05). No correlation was found between maternal SARS-CoV-2 Viral Load and maternal Disease Severity/Neonatal Outcomes. Conclusions: To the best of our knowledge, this study was the first one examining the association between maternal SARS-CoV-2 Viral Load and maternal/Neonatal Outcomes. It was suggested that Viral Load may not have been used for predicting the severity of maternal disease and maternal/Neonatal Outcomes.

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APA: Copy

Yasa, Beril, KARABULUT, NURAN, Ilker Uslu, Sait, Memur, Seyma, Yavuzcan Ozturk, Dilek, Bagci, Onur, Sema Can Buker, Halime, Polat, Ibrahim, & CETINKAYA, MERIH. (2023). SARS-CoV-2 Viral Load in PregnantWomen and Association with Maternal Disease Severity and Neonatal Outcomes. IRANIAN JOURNAL OF PEDIATRICS, 33(1), 00-00. SID. https://sid.ir/paper/1099000/en

Vancouver: Copy

Yasa Beril, KARABULUT NURAN, Ilker Uslu Sait, Memur Seyma, Yavuzcan Ozturk Dilek, Bagci Onur, Sema Can Buker Halime, Polat Ibrahim, CETINKAYA MERIH. SARS-CoV-2 Viral Load in PregnantWomen and Association with Maternal Disease Severity and Neonatal Outcomes. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2023;33(1):00-00. Available from: https://sid.ir/paper/1099000/en

IEEE: Copy

Beril Yasa, NURAN KARABULUT, Sait Ilker Uslu, Seyma Memur, Dilek Yavuzcan Ozturk, Onur Bagci, Halime Sema Can Buker, Ibrahim Polat, and MERIH CETINKAYA, “SARS-CoV-2 Viral Load in PregnantWomen and Association with Maternal Disease Severity and Neonatal Outcomes,” IRANIAN JOURNAL OF PEDIATRICS, vol. 33, no. 1, pp. 00–00, 2023, [Online]. Available: https://sid.ir/paper/1099000/en

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