Targeting Mitochondrial-Nuclear Apoptotic Signaling Pathways, Metabolic Pathways and Reversal of Doxorubicin (DOX) Cell Resistance in MCF-7 and MDA‑, MB-231 Cancer Cell Lines by Sambucus Nigra (SNA)

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GHANBARI ALI; ROSHANKHAH SHIVA; SALAHSHOOR MOHAMMAD REZA; JALILI CYRUS; Esmaeli Mojtaba

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Journal Paper

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Journal: Archives of Breast Cancer Year:2022 | Volume:9 | Issue:1 Page(s): 83-95

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Title

Targeting Mitochondrial-Nuclear Apoptotic Signaling Pathways, Metabolic Pathways and Reversal of Doxorubicin (DOX) Cell Resistance in MCF-7 and MDA‑, MB-231 Cancer Cell Lines by Sambucus Nigra (SNA)

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Keywords

Breast cancer

Doxorubicin

Drug resistance

Sambucus nigra

Abstract

Background: The study aimed to assess the effect of anti-tumor and anti-proliferative properties of Sambucus nigra (SNA) on MCF-7 and MDA-MB-231 breast tumor cell lines. Methods: The cytotoxicity of SNA was assessed based on dose/time by the MTT assay. Also, the influence of SNA on apoptotic pathways, cellular and metabolic resistance in these cell lines was examined by real-time PCR, lipid peroxidase was measured by malondialdehyde (MDA) and the effect of apoptosis and necrosis was determined by flow cytometry. Results: Our data showed that DOX, SNA, and DOX + SNA treatment induced the expression of p53, Bax, Bcl-2, Caspase-3, and 8 levels involved in the apoptotic pathways. ATP binding cassette subfamily B member 4 (ABCB4) gene expression was decreased in MDA‑, MB-231 Breast cancer cells compared to MCF-7. Also, we observed that DOX, SNA, and DOX + SNA treatment induced expression of Monocarboxylate transporters (MCTs) metabolic pathways such as MCT1 and MCT4. Conclusion: Overall, the outcomes of this investigation show that the combination of SNA-Doxorubicin (DOX) in different groups of these cancer cells, especially in the MDA‑, MB-231 cell lines synergistically intensified the induction of apoptosis in them. SNA enhances the anti-cancer effects of DOX to induce cellular apoptosis, alter metabolic pathways, and reduce cellular resistance. The research highlights the promising use of SNA as a chemosensitizer in the chemotherapy.

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APA: Copy

GHANBARI, ALI, ROSHANKHAH, SHIVA, SALAHSHOOR, MOHAMMAD REZA, JALILI, CYRUS, & Esmaeli, Mojtaba. (2022). Targeting Mitochondrial-Nuclear Apoptotic Signaling Pathways, Metabolic Pathways and Reversal of Doxorubicin (DOX) Cell Resistance in MCF-7 and MDA‑, MB-231 Cancer Cell Lines by Sambucus Nigra (SNA). ARCHIVES OF BREAST CANCER, 9(1), 83-95. SID. https://sid.ir/paper/1099822/en

Vancouver: Copy

GHANBARI ALI, ROSHANKHAH SHIVA, SALAHSHOOR MOHAMMAD REZA, JALILI CYRUS, Esmaeli Mojtaba. Targeting Mitochondrial-Nuclear Apoptotic Signaling Pathways, Metabolic Pathways and Reversal of Doxorubicin (DOX) Cell Resistance in MCF-7 and MDA‑, MB-231 Cancer Cell Lines by Sambucus Nigra (SNA). ARCHIVES OF BREAST CANCER[Internet]. 2022;9(1):83-95. Available from: https://sid.ir/paper/1099822/en

IEEE: Copy

ALI GHANBARI, SHIVA ROSHANKHAH, MOHAMMAD REZA SALAHSHOOR, CYRUS JALILI, and Mojtaba Esmaeli, “Targeting Mitochondrial-Nuclear Apoptotic Signaling Pathways, Metabolic Pathways and Reversal of Doxorubicin (DOX) Cell Resistance in MCF-7 and MDA‑, MB-231 Cancer Cell Lines by Sambucus Nigra (SNA),” ARCHIVES OF BREAST CANCER, vol. 9, no. 1, pp. 83–95, 2022, [Online]. Available: https://sid.ir/paper/1099822/en

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