THE EFFECT OF ORAL CLONIDINE PREMEDICATION ON HEMODYNAMIC RESPONSES DURING GYNECOLOGIC LAPARASCOPY UNDER GENERAL ANESTHESIA

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HASANI V.A.; MOHAMMAD TAHERI F.; MEHDIZADEH A.

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Journal: Razi Journal of Medical Sciences Year:2006 | Volume:13 | Issue:50 Page(s): 39-46

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Title

THE EFFECT OF ORAL CLONIDINE PREMEDICATION ON HEMODYNAMIC RESPONSES DURING GYNECOLOGIC LAPARASCOPY UNDER GENERAL ANESTHESIA

Author(s)

HASANI V.A. | MOHAMMAD TAHERI F. | MEHDIZADEH A. | Issue Writer Certificate

Keywords

CLONIDINEQ3

REMIFENTANILQ3

LAPAROSCOPYQ3

CIS-ATRACURIUMQ2

Abstract

Background & Aim: CLONIDINE, an alpha 2 agonist, attenuates sympathetic responses during general anesthesia and improves the intra-operative hemodynamic stability. In this randomized double blinded clinical trial study, we report the effects of 300 μg oral CLONIDINE premedication (n=22) or placebo (n=22) on hemodynamic alteration during gynecologic laparoscopic surgery, under general anesthesia. Previous works have reported the effectiveness of CLONIDINE on blunting the sympathetic responses during open surgeries.Patients & Methods: Anesthesia consisted of isoflurane/O2 and REMIFENTANIL. Muscle relaxation was maintained by cisatracurium. Hemodynamic data were obtained at 5 epochs: base, after induction of anesthesia, insufflation (after peumoperitoneum, supine position), trendelenburg 30 degrees, and end (after supine extubation.Results: There was a significant increase in systolic blood pressure during peritoneal insufflation and trendelenburg position in patients in the control group (129±23, 115±29 mmhg) compared with patients in the CLONIDINE group(126±34, 116±25 mmhg), P<0.05. Peritoneal insufflation and trendelenburg positioning resulted in significant increase in systolic blood pressure compared with base, in patients in both groups (control 127±15 mmhg to 129±23 & 126±34 mmhg; CLONIDINE 109±19mmhg to 115±29 & 116±25 mmhg, P<0.05). After extubation, there was significant increase in diastolic BP in CLONIDINE group: (98±32 mmhg vs 86±8mmhg in control group). During LAPAROSCOPY, there was a significant increase in diastolic BP in the control group (89±16 mmhg vs 75±18 mmhg in CLONIDINE group; P<0.05). There was a significant increase in diastolic BP in the patients in CLONIDINE group (98±32) compared with the patients in control group (86±8) P<0.05. There was significant slower HR during the procedure in both groups (71±29 bpm, 63±22 vs base 85±22bpm, 85±39).Conclusion: It seems that CLONIDINE can not blunt the hemodynamic responses in hyperdynamic phases after gynecologic LAPAROSCOPY in spite of its effectiveness during the procedure.

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APA: Copy

HASANI, V.A., MOHAMMAD TAHERI, F., & MEHDIZADEH, A.. (2006). THE EFFECT OF ORAL CLONIDINE PREMEDICATION ON HEMODYNAMIC RESPONSES DURING GYNECOLOGIC LAPARASCOPY UNDER GENERAL ANESTHESIA. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 13(50), 39-46. SID. https://sid.ir/paper/11044/en

Vancouver: Copy

HASANI V.A., MOHAMMAD TAHERI F., MEHDIZADEH A.. THE EFFECT OF ORAL CLONIDINE PREMEDICATION ON HEMODYNAMIC RESPONSES DURING GYNECOLOGIC LAPARASCOPY UNDER GENERAL ANESTHESIA. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2006;13(50):39-46. Available from: https://sid.ir/paper/11044/en

IEEE: Copy

V.A. HASANI, F. MOHAMMAD TAHERI, and A. MEHDIZADEH, “THE EFFECT OF ORAL CLONIDINE PREMEDICATION ON HEMODYNAMIC RESPONSES DURING GYNECOLOGIC LAPARASCOPY UNDER GENERAL ANESTHESIA,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 13, no. 50, pp. 39–46, 2006, [Online]. Available: https://sid.ir/paper/11044/en

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