A COMPARATIVE STUDY OF THE EFFECTIVENESS AND SIDE-EFFECTS OF THE TWO EUROMUSCULAR BLOCKING AGENT, ATRACURIUM AND CIS-ATRACURIUM

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GHIAMAT M.M.; RAZAVI P.

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2002 | Volume:22 | Issue:39 Page(s): 4-9

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Title

A COMPARATIVE STUDY OF THE EFFECTIVENESS AND SIDE-EFFECTS OF THE TWO EUROMUSCULAR BLOCKING AGENT, ATRACURIUM AND CIS-ATRACURIUM

Author(s)

GHIAMAT M.M. | RAZAVI P. | Issue Writer Certificate

Keywords

ATRACURIUMQ4

CIS-ATRACURIUMQ3

EFFECTIVENESSQ3

HEMODYNAMIC CHANGESQ2

Abstract

Among the drugs falling under the category of muscular relaxants with medium periods of EFFECTIVENESS, ATRACURIUM can be prescribed to kidney and liver disease patients readily due to its independent elimination from the internal body organs through the plasma mechanism and the Hofmann mechanism. It does not accumulate in the body on long-term intake or repeated dosages. Cis-ATRACURIUM is a refined isomer of ATRACURIUM which has the properties of ATRACURIUM, and in addition, brings about cardiovascular stability in the patient due to non-release of histamine during intake.In this clinical experiment, including two groups of 25, the appropriate time for tracheal intubation was calculated after administration of ATRACURIUM (0.5 mg/kg) and Cis-ATRACURIUM (0.15mg/kg) and based on complete ceasing of the response of TOF (Train of Four). The time average obtained for the ATRACURIUM group was 3.6 minutes (SD=0.4), and for the Cis-ATRACURIUM group, 3.8 minutes (SD=0.3). (p>0.05)With regard to the EFFECTIVENESS period, the average of the return of 25% of TOF response was calculated at 29 minutes (SD=5) in the ATRACURIUM group, and 56 minutes (SD=6) in the Cis-ATRACURIUM group. (p<0.005)Concerning changes in the blood pressure and heart rate, there was a fall in blood pressure in 52%, a rise in blood pressure in 16%, and no changes in blood pressure in 32% of the patients of group A after administration of ATRACURIUM. There was a fall in blood pressure in 16%, a rise in blood pressure in 12%, and no changes in blood pressure in 72% of the patients of group B after administration of Cis-ATRACURIUM. There was also similar changes in the heart rate as with the blood pressure changes in the two groups.Based on the results obtained and with due regard to the common advantages of ATRACURIUM and Cis-ATRACURIUM, and the higher cardiovascular stability provided by the administration of Cis-ATRACURIUM, this drug can prove an appropriate substitute in surgical operations with medium to long time.

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APA: Copy

GHIAMAT, M.M., & RAZAVI, P.. (2002). A COMPARATIVE STUDY OF THE EFFECTIVENESS AND SIDE-EFFECTS OF THE TWO EUROMUSCULAR BLOCKING AGENT, ATRACURIUM AND CIS-ATRACURIUM. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 22(39), 4-9. SID. https://sid.ir/paper/63384/en

Vancouver: Copy

GHIAMAT M.M., RAZAVI P.. A COMPARATIVE STUDY OF THE EFFECTIVENESS AND SIDE-EFFECTS OF THE TWO EUROMUSCULAR BLOCKING AGENT, ATRACURIUM AND CIS-ATRACURIUM. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2002;22(39):4-9. Available from: https://sid.ir/paper/63384/en

IEEE: Copy

M.M. GHIAMAT, and P. RAZAVI, “A COMPARATIVE STUDY OF THE EFFECTIVENESS AND SIDE-EFFECTS OF THE TWO EUROMUSCULAR BLOCKING AGENT, ATRACURIUM AND CIS-ATRACURIUM,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 22, no. 39, pp. 4–9, 2002, [Online]. Available: https://sid.ir/paper/63384/en

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