The effect of 4 weeks of exercise preconditioning on soluble amyloid beta level and memory impairment in rats with Alzheimer's disease induced by Aβ 1-42 injection

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KHODADADI DAVAR; GHARAKHANLOU REZA; NAGHDI NASER; SALIMI MONA; Azimi Seyyed Mohammad; SHAHED ATABAK

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Journal: Razi Journal of Medical Sciences Year:2018 | Volume:24 | Issue:165 Page(s): 74-84

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Title

The effect of 4 weeks of exercise preconditioning on soluble amyloid beta level and memory impairment in rats with Alzheimer's disease induced by Aβ 1-42 injection

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Keywords

Alzheimer's diseaseQ2

Exercise preconditioningQ1

Soluble amyloid betaQ1

sLRP-1Q1

Abstract

Background: Alzheimer's disease (AD) is the most common form of dementia and amyloid peptides playing a central role in its pathogenesis. Recently, regular exercise has been considered as one of the most important non-pharmacological mechanisms to contrast with AD. Therefore, the aim of the present study was to investigate the effect of 4 weeks of Exercise preconditioning on the level of soluble amyloid and memory impairment in rats with AD induced by Aβ 1-42 injection. Methods: Eighty four male rats with mean± SD weight of 195± 20 g were randomly divided into two groups of aerobic training or resting for 4 weeks. Then, each group was subdivided into 3 subgroups of AD, sham and non-injected. Forty eight hours after the last training session, injection of Aβ 1-42 or DMSO into the hippocampus was performed. Seven days after surgery, rats of each groups were either sacrificed (7 rats) or subjected to behavioral testing (7 rats), randomly. Following the collection of blood samples in the victim's rats, the hippocampal tissue was extracted and the levels of Aβ 1-42 in plasma and hippocampus, as well as the plasma level of the soluble Low-Density Lipoprotein Receptor-Related Protein-1 (sLRP-1) evaluated. Results: The results showed that in the exercise + AD group, hippocampal level of Aβ 1-42 were lower, and plasma level of Aβ 1-42 were higher than the AD group (p<0. 001). Plasma sLRP-1 level in the exercise + AD group was also greater than the AD group (p<0. 001). Moreover, spatial learning and memory were significantly better in the exercise + AD than AD group (p<0. 01). Conclusion: It seems that 4 weeks of Exercise preconditioning could reduce the loss of spatial learning and memory through increasing Soluble amyloid beta clearance from the brain.

Cites

The Effect of 4 Weeks of Aerobic Training on Spatial Learning, Memory Performance and Mitochondrial Dynamics in the Hippocampal Tissue of Old Rats

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APA: Copy

KHODADADI, DAVAR, GHARAKHANLOU, REZA, NAGHDI, NASER, SALIMI, MONA, Azimi, Seyyed Mohammad, & SHAHED, ATABAK. (2018). The effect of 4 weeks of exercise preconditioning on soluble amyloid beta level and memory impairment in rats with Alzheimer's disease induced by Aβ 1-42 injection. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 24(165 ), 74-84. SID. https://sid.ir/paper/11054/en

Vancouver: Copy

KHODADADI DAVAR, GHARAKHANLOU REZA, NAGHDI NASER, SALIMI MONA, Azimi Seyyed Mohammad, SHAHED ATABAK. The effect of 4 weeks of exercise preconditioning on soluble amyloid beta level and memory impairment in rats with Alzheimer's disease induced by Aβ 1-42 injection. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;24(165 ):74-84. Available from: https://sid.ir/paper/11054/en

IEEE: Copy

DAVAR KHODADADI, REZA GHARAKHANLOU, NASER NAGHDI, MONA SALIMI, Seyyed Mohammad Azimi, and ATABAK SHAHED, “The effect of 4 weeks of exercise preconditioning on soluble amyloid beta level and memory impairment in rats with Alzheimer's disease induced by Aβ 1-42 injection,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 24, no. 165 , pp. 74–84, 2018, [Online]. Available: https://sid.ir/paper/11054/en

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