SOMATIC CELL REPROGRAMMING ON THE PROGRESS ROAD TOWARD ESTABLISHMENT OF INDUCED PLURIPOTENT STEM CELL AS A SCLERODERMA DISEASE MODEL

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RANJBAR NIAVOL FAZELEH; BAHARVAND HOSSEIN; AGHDAMI NASSER

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Journal: Razi Journal of Medical Sciences Year:2016 | Volume:23 | Issue:146 Page(s): 36-45

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Title

SOMATIC CELL REPROGRAMMING ON THE PROGRESS ROAD TOWARD ESTABLISHMENT OF INDUCED PLURIPOTENT STEM CELL AS A SCLERODERMA DISEASE MODEL

Author(s)

RANJBAR NIAVOL FAZELEH | BAHARVAND HOSSEIN | AGHDAMI NASSER | Issue Writer Certificate

Keywords

SCLERODERMAQ1

AUTOIMMUNE DISEASESQ1

PATIENT-BASE SYSTEMQ1

MOLECULAR AND DEVELOPMENTAL DEFECTSQ1

NOVEL THERAPEUTICSQ1

Abstract

SCLERODERMA as one of the important AUTOIMMUNE DISEASES, leads to death of endothelial cells as of the early events of this disease. The lack of repair after the loss of endothelial cells is observed in these patients though its cause has remained unknown. The development of effective treatments for many rheumatoid diseases requires a better understanding of the pathophysiological mechanisms involved in the disease. Because of physiological and anatomical and developmental differences between human and other species, a proper SCLERODERMA animal model which represents all aspects of the disease has not been generated yet. Thus, making a patient-based system to mimic a developmental defect and evaluating its probable repair mechanism is considered as a necessity. For this reason, development of a model system as an evaluation tool to show MOLECULAR AND DEVELOPMENTAL DEFECTS and also to explain the possible repair mechanism is deemed necessary. Like other studies using patient specific cell as a limitless source could provide new hope for development of novel therapeutic approaches for patients with SCLERODERMA.

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APA: Copy

RANJBAR NIAVOL, FAZELEH, BAHARVAND, HOSSEIN, & AGHDAMI, NASSER. (2016). SOMATIC CELL REPROGRAMMING ON THE PROGRESS ROAD TOWARD ESTABLISHMENT OF INDUCED PLURIPOTENT STEM CELL AS A SCLERODERMA DISEASE MODEL. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 23(146), 36-45. SID. https://sid.ir/paper/11107/en

Vancouver: Copy

RANJBAR NIAVOL FAZELEH, BAHARVAND HOSSEIN, AGHDAMI NASSER. SOMATIC CELL REPROGRAMMING ON THE PROGRESS ROAD TOWARD ESTABLISHMENT OF INDUCED PLURIPOTENT STEM CELL AS A SCLERODERMA DISEASE MODEL. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2016;23(146):36-45. Available from: https://sid.ir/paper/11107/en

IEEE: Copy

FAZELEH RANJBAR NIAVOL, HOSSEIN BAHARVAND, and NASSER AGHDAMI, “SOMATIC CELL REPROGRAMMING ON THE PROGRESS ROAD TOWARD ESTABLISHMENT OF INDUCED PLURIPOTENT STEM CELL AS A SCLERODERMA DISEASE MODEL,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 23, no. 146, pp. 36–45, 2016, [Online]. Available: https://sid.ir/paper/11107/en

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