The protective effect of Nigella Sativa L. seed's hydro-alcoholic extract on liver toxicity induced by gentamicin in male rats

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KHAZAEI MARYAM; MIRAZI NASER

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Journal: Razi Journal of Medical Sciences Year:2018 | Volume:24 | Issue:164 Page(s): 74-84

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Information Journal Paper

Title

The protective effect of Nigella Sativa L. seed's hydro-alcoholic extract on liver toxicity induced by gentamicin in male rats

Author(s)

KHAZAEI MARYAM | MIRAZI NASER | Issue Writer Certificate

Keywords

Nigella sativaQ3

liver toxicityQ2

Liver enzymesQ2

GentamicinQ3

RatQ2

Abstract

Background: Gentamicin is an aminoglycosides antibiotic which is used to treat several types of bacterial infections. The aim of this study was to evaluate the effects of Nigella sativa L. extract (NSE) on liver toxicity and serum level of Liver enzymes in Rats induced by Gentamicin. Methods: In the present experimental study, 42 Wistar male Rats were divided randomly into 6 groups includes: control (normal saline 2ml/kg, i. p), Gentamicin (Gentamicin 80mg/kg/day, i. p), positive control (400mg/kg NSE, i. p) and treated groups 1, 2, 3 (Gentamicin 80mg/kg/day+ NSE 200, 400 and 800 mg/kg respectively, i. p). Nigella sativa extract was injected for 7 days after ten days period of Gentamicin injection. After the examination the blood samples were collected from heart directly and the serum of ALT, AST and ALP Liver enzymes were measured. Microscopic studies of hepatic tissue were done. All data analyzed with ANOVA and Tukey test. Results: Gentamicin caused necrosis and inflammation in the liver tissue and significantly increased serum level of Liver enzymes (p<0. 001). Treatment with NSE significantly decreased serum level of Liver enzymes in treated groups compared with the group receiving Gentamicin (p<0. 001). The greatest impact was created in high dose of NSE. Conclusion: Gentamicin can cause necrosis and inflammation effect in liver tissue. The Nigella sativa seed extract have antioxidant and flavonoid compounds that can decrease toxic effect of Gentamicin in liver tissue.

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APA: Copy

KHAZAEI, MARYAM, & MIRAZI, NASER. (2018). The protective effect of Nigella Sativa L. seed's hydro-alcoholic extract on liver toxicity induced by gentamicin in male rats. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 24(164 ), 74-84. SID. https://sid.ir/paper/11115/en

Vancouver: Copy

KHAZAEI MARYAM, MIRAZI NASER. The protective effect of Nigella Sativa L. seed's hydro-alcoholic extract on liver toxicity induced by gentamicin in male rats. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;24(164 ):74-84. Available from: https://sid.ir/paper/11115/en

IEEE: Copy

MARYAM KHAZAEI, and NASER MIRAZI, “The protective effect of Nigella Sativa L. seed's hydro-alcoholic extract on liver toxicity induced by gentamicin in male rats,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 24, no. 164 , pp. 74–84, 2018, [Online]. Available: https://sid.ir/paper/11115/en

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