Long Non-coding RNA snaR Promotes Proliferation in EGFR Wild Type Non-Small Cell Lung Cancer Cells

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Ameli Mojarad Melika; Ameli Mojarad Mandana; Pourmahdian Alireza

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Journal Paper

Paper Information

Journal: International Journal of Molecular and Cellular Medicine Year:2021 | Volume:10 | Issue:4 Page(s): 258-264

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Title

Long Non-coding RNA snaR Promotes Proliferation in EGFR Wild Type Non-Small Cell Lung Cancer Cells

Author(s)

Ameli Mojarad Melika | Ameli Mojarad Mandana | Pourmahdian Alireza | Issue Writer Certificate

Keywords

Long non-coding RNA

snaR

non-smallcell lung carcinoma

EGFR

Abstract

Lung cancer is the second most common cancer and has high morbidity and mortality worldwide with non-small cell lung cancer (NSCLC) accounting for 85% of the cases. Over-expression of epidermal growth factor receptor (EGFR) has been clarified in different cancers, and has been shown to have a crucial role in tumor progression. In this study, we evaluated Long non-coding RNA small NF90-associated RNA (snaR) expression in different EGFR-statue cell lines. Knockdown experiments were conducted to analyze snaR expression in selected cell lines. MTT and transwell assays were respectively employed to evaluate the proliferative and invasive abilities of NSCLC cells. The expression of snaR was remarkably up-regulated in SPC-A1 and A549 wild-type EGFR cell lines. Down regulation of snaR with small interfering RNA significantly inhibited cell invasion as well as proliferation of SPC-A1 and A549 cells. Our results indicate that snaR may be a potential therapeutic biomarker for NSCLC.

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APA: Copy

Ameli Mojarad, Melika, Ameli Mojarad, Mandana, & Pourmahdian, Alireza. (2021). Long Non-coding RNA snaR Promotes Proliferation in EGFR Wild Type Non-Small Cell Lung Cancer Cells. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 10(4), 258-264. SID. https://sid.ir/paper/1114746/en

Vancouver: Copy

Ameli Mojarad Melika, Ameli Mojarad Mandana, Pourmahdian Alireza. Long Non-coding RNA snaR Promotes Proliferation in EGFR Wild Type Non-Small Cell Lung Cancer Cells. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2021;10(4):258-264. Available from: https://sid.ir/paper/1114746/en

IEEE: Copy

Melika Ameli Mojarad, Mandana Ameli Mojarad, and Alireza Pourmahdian, “Long Non-coding RNA snaR Promotes Proliferation in EGFR Wild Type Non-Small Cell Lung Cancer Cells,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 10, no. 4, pp. 258–264, 2021, [Online]. Available: https://sid.ir/paper/1114746/en

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