PROTECTIVE AND THERAPEUTIC EFFECTS OF FUMARIA OFFICINAL IS AQUEOUS EXTRACT AGAINST ACETAMINOPHEN- INDUCED CHRONIC HEPATOTOXICITY IN RATS

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GHOLAMI MARYAM; VASEIE MARZIEH; ERFANI SOHEILA; NAJJARZADEH MASOUD; HEMMATI MINA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Razi Journal of Medical Sciences Year:2016 | Volume:23 | Issue:147 Page(s): 56-63

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Title

PROTECTIVE AND THERAPEUTIC EFFECTS OF FUMARIA OFFICINAL IS AQUEOUS EXTRACT AGAINST ACETAMINOPHEN- INDUCED CHRONIC HEPATOTOXICITY IN RATS

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Keywords

HEPATOTOXICITYQ1

FUMARIA OFFICINAL ISQ1

LIVER ENZYMESQ2

LIPID PROFILEQ2

ANTIOXIDANTSQ2

Abstract

Background: Hepatoprotective effects of plants with antioxidant properties have been demonstrated. Considering the importance of drug-induced HEPATOTOXICITY as a major cause of liver damage, the present study carried out to investigate the protective and therapeutic effects of FUMARIA OFFICINAL IS extract against HEPATOTOXICITY induced by acetaminophen in rats.Methods: 35 adult male Wistar Albino rats randomly were divided into 7 groups: (1) healthy control, (2) positive control rats [intraperitoneal injection of acetaminophen (150mg/kg)], (3) hepatotoxic rats treated with silybum marianum (100mg/kg) once daily, (4) and (5) hepatotoxic rats treated with Fumaria aqueous extract once daily at doses 250 and 500mg/kg, respectively for 2 weeks at the time of acetaminophen injection and (6) and (7) protective experimental rats that were treated with aqueous extract of Fumaria once daily at doses 250 and 500mg/kg, respectively, before drug injection. For groups 6 and 7, after 2 weeks of oral treatment, acetaminophen was injected and treatment continued for 2 weeks. At the end of treatment period serum level of functional liver markers (ALT, AST, ALP, and LDH), LIPID PROFILE, malondialdehyde and total antioxidant capacity were measured. The data was analyzed by one way ANOVA test.Results: Fumaria reduced the elevated LIVER ENZYMES levels and also improved LIPID PROFILE. Furthermore this plant reduced lipid peroxidation and increased total antioxidant capacity. Protective effects of Fumaria in prevention groups were notable compared with therapeutic groups.Conclusion: Our results demonstrated that Fumaria have protective and therapeutic effect on experimentally acetaminophen-induced HEPATOTOXICITY in rats. This protective effect might be due to various flavonoids in different plants and it should be considered when designing new drugs for liver toxicity treatment.

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