The Study of Exon 2 of BMP15 and Exon 9 of BMPR1B Gene Polymorphisms in Iranian Infertile Women with Premature Ovarian Failure

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Zarrin Parvane; Tabatabaei Seyede Nafise; Moshtaghiun Seyed Mohammad; FALAHATI ALI; GHASEMI NASRIN

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2022 | Volume:65 | Issue:4 Page(s): 1714-1729

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Title

The Study of Exon 2 of BMP15 and Exon 9 of BMPR1B Gene Polymorphisms in Iranian Infertile Women with Premature Ovarian Failure

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Keywords

Premature Ovarian Failure

Single Nucleotide Polymorphism

Female Infertility

BMP15

BMPR1B

Abstract

Introduction: Premature Ovarian Failure (POF) is the end of ovarian activity before the age of 40, which is associated with low levels of sex hormones and high levels of gonadotropins. Genetic factors play an essential role in POF. BMP15 and its receptor BMPR1B are members of the TGFβ,superfamily that are expressed in the ovaries and are involved in folliculogenesis. Any changes in these genes may disrupt them. So, this study aimed to assess 4 SNPs in exon 2 of BMP15 and 2 SNPs in exon 9 of BMPR1B genes as candidate SNPs in infertile Iranian women with POF. Materials and Methods: Using the Uniprot database and PCR-SSCP methods, the link between SNPs 443T>C, 468G>A, 538G>A, 598C>T of BMP15, and 945G>A, 1020A>G of BMPR1B gene in 45 women with POF and 45 healthy women with children, without any history of diseases related to folliculogenesis and ovulation were examined as controls. Then, PCR products with mobility shift were sent for sequencing and the results were analyzed with CLC software Results: The results of gel electrophoresis, SSCP, and sequencing graphs of none of the SNPs, did not show a change in the sequence of the patients compared to the control samples. Conclusion: According to the key role of BMP15 in folliculogenesis and previous reports,BMP15 may be effective in the occurrence of POF. The absence of SNPs in these POF patients can be due to the small size of the studied samples and their genetic differences.

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APA: Copy

Zarrin, Parvane, Tabatabaei, Seyede Nafise, Moshtaghiun, Seyed Mohammad, FALAHATI, ALI, & GHASEMI, NASRIN. (2022). The Study of Exon 2 of BMP15 and Exon 9 of BMPR1B Gene Polymorphisms in Iranian Infertile Women with Premature Ovarian Failure. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 65(4 ), 1714-1729. SID. https://sid.ir/paper/1121489/en

Vancouver: Copy

Zarrin Parvane, Tabatabaei Seyede Nafise, Moshtaghiun Seyed Mohammad, FALAHATI ALI, GHASEMI NASRIN. The Study of Exon 2 of BMP15 and Exon 9 of BMPR1B Gene Polymorphisms in Iranian Infertile Women with Premature Ovarian Failure. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2022;65(4 ):1714-1729. Available from: https://sid.ir/paper/1121489/en

IEEE: Copy

Parvane Zarrin, Seyede Nafise Tabatabaei, Seyed Mohammad Moshtaghiun, ALI FALAHATI, and NASRIN GHASEMI, “The Study of Exon 2 of BMP15 and Exon 9 of BMPR1B Gene Polymorphisms in Iranian Infertile Women with Premature Ovarian Failure,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 65, no. 4 , pp. 1714–1729, 2022, [Online]. Available: https://sid.ir/paper/1121489/en

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