A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease

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Febrinasari Ratih Puspita; Putri Indah Sagitaisna; Rezkita Bastomy Eka; Irving Steven; Azmiardi Akhmad; Pribadi Rabbinu Rangga; Simadibrata Marcellus; Sari Yulia

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Journal: Caspian Journal of Internal Medicine Year:2023 | Volume:14 | Issue:3 Page(s): 412-424

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Title

A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease

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Keywords

Inflammatory bowel disease

Advanced glycation end products receptor

Genetic polymorphisms

Meta-analysis

Systematic review

Abstract

Background: In the pathogenesis of Inflammatory bowel disease (IBD), the advanced glycation end product receptor (RAGE) has been involved. IBD is classified into Chron’, s disease (CD) and ulcerative colitis (UC). The promoter gene of the RAGE gene was discovered to have had unique polymorphisms that increased its transcriptional activity. This study, therefore, used a Systematic review and Meta-analysis to examine the relationship between the RAGE gene polymorphism and the risk of IBD. Methods: Databases such as PubMed, Scopus, and Cochrane library were searched to identify the relationship between RAGE gene polymorphisms and IBD susceptibility. We identified three Single Nucleotide Polymorphism (SNPs) (RAGE-429T/C, 374T/A, and G82S). The data were analyzed by RevMan 5. 4. Results: Four studies (932 cases/1366 controls) were included. The findings showed no relationship between RAGE –, 429T/C and –, G82S polymorphisms and the risk of IBD in all genetic models significantly. TT genotype of RAGE –, 374T/A polymorphisms was related to increased CD risk (OR=1. 37,95%CI=1. 04-1. 81,P=0. 02), while TA genotype was determined to be a protective factor (OR=0. 75,95%CI=0. 57-0. 99,P=0. 04). In UC, A allele of RAGE-374T/A was related to increase risk (OR=1. 26,95%CI=1. 04-1. 53,P=0. 02), while T allele was determined to decrease risk (OR=0. 79,95%CI= 0. 65-0. 96,P=0. 02). Conclusions: Our findings demonstrated that TT genotype and A allele of RAGE 374T/A polymorphisms were related to CD and UC risks, respectively, while the TA genotype and T allele possibly had a protective effect. RAGE –, 429T/C and RAGE –,G82S polymorphisms were not related to increased IBD risk.

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APA: Copy

Febrinasari, Ratih Puspita, Putri, Indah Sagitaisna, Rezkita, Bastomy Eka, Irving, Steven, Azmiardi, Akhmad, Pribadi, Rabbinu Rangga, Simadibrata, Marcellus, & Sari, Yulia. (2023). A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease. CASPIAN JOURNAL OF INTERNAL MEDICINE, 14(3), 412-424. SID. https://sid.ir/paper/1128485/en

Vancouver: Copy

Febrinasari Ratih Puspita, Putri Indah Sagitaisna, Rezkita Bastomy Eka, Irving Steven, Azmiardi Akhmad, Pribadi Rabbinu Rangga, Simadibrata Marcellus, Sari Yulia. A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2023;14(3):412-424. Available from: https://sid.ir/paper/1128485/en

IEEE: Copy

Ratih Puspita Febrinasari, Indah Sagitaisna Putri, Bastomy Eka Rezkita, Steven Irving, Akhmad Azmiardi, Rabbinu Rangga Pribadi, Marcellus Simadibrata, and Yulia Sari, “A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 14, no. 3, pp. 412–424, 2023, [Online]. Available: https://sid.ir/paper/1128485/en

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