Occurrence of butyrylcholinesterase polymorphisms in patients undergoing surgery in Slovakia

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Cuchrac Lukas; MydlarovaBlascakova Marta; Firment Jozef; Simonova Jana; Jarmila Bernasovska; Vaskova Janka

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Journal Paper

Paper Information

Journal: Caspian Journal of Internal Medicine Year:2023 | Volume:14 | Issue:3 Page(s): 490-494

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Title

Occurrence of butyrylcholinesterase polymorphisms in patients undergoing surgery in Slovakia

Author(s)

Keywords

Butyrylcholinesterase

Cholinesterase

Neuromuscular blocker

Polymorphism

Residual curarization

Abstract

Background: Post-operative Residual curarization is a persisting problem, characterized by muscle fatigue, exhaustion or paresis, caused by the use of neuromuscular blocking agents with prolonged postoperative effect. Genetically, determined changes in Cholinesterase activity can be a major reason for persistent muscle blockade after administration of muscle relaxants. Methods: Regarding the subsistence of Polymorphisms in the plasma Cholinesterase gene causing change in enzyme activity and metabolism of applied drugs, we investigated the frequency of two Polymorphisms known to reduce its activity significantly in patients undergoing surgery. Results: Primary results show a relatively high occurrence of plasma Cholinesterase K risk allele (18. 75%). Conclusion: Characterization of the lacking information about genetic background of changes in plasma Cholinesterase activity within Slovakia may allow for easier decisionmaking in clinical practice when selecting alternative neuromuscular blocking and also reversal agents.

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APA: Copy

Cuchrac, Lukas, MydlarovaBlascakova, Marta, Firment, Jozef, Simonova, Jana, Jarmila, Bernasovska, & Vaskova, Janka. (2023). Occurrence of butyrylcholinesterase polymorphisms in patients undergoing surgery in Slovakia. CASPIAN JOURNAL OF INTERNAL MEDICINE, 14(3), 490-494. SID. https://sid.ir/paper/1128495/en

Vancouver: Copy

Cuchrac Lukas, MydlarovaBlascakova Marta, Firment Jozef, Simonova Jana, Jarmila Bernasovska, Vaskova Janka. Occurrence of butyrylcholinesterase polymorphisms in patients undergoing surgery in Slovakia. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2023;14(3):490-494. Available from: https://sid.ir/paper/1128495/en

IEEE: Copy

Lukas Cuchrac, Marta MydlarovaBlascakova, Jozef Firment, Jana Simonova, Bernasovska Jarmila, and Janka Vaskova, “Occurrence of butyrylcholinesterase polymorphisms in patients undergoing surgery in Slovakia,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 14, no. 3, pp. 490–494, 2023, [Online]. Available: https://sid.ir/paper/1128495/en

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