HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in non-diabetic and non-obese patients

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Eid Mohamed; Sayed Sherif A.; Zaki Nayel A.; Hamdy Amera M.F.; Altaher Ali M.A.

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Journal: Caspian Journal of Internal Medicine Year:2023 | Volume:14 | Issue:3 Page(s): 495-506

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Title

HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in non-diabetic and non-obese patients

Author(s)

Keywords

Coronary artery disease

Coronary atherosclerosis

HOMA estimated insulin resistance

Abstract

Background: Insulin resistance (IR) examined by homeostasis model assessment of insulin resistance (HOMA-IR) measures increased carotid atherosclerosis risks in nondiabetic and non-obese persons. The information about the relationship between IR and Coronary atherosclerosis severity among non-diabetic and non-obese population showed conflicting results. The goal of the current study was to assess the relationship that links IR and Coronary artery disease (CAD) among non-diabetic and non-obese Egyptian populations. Methods: 112 non-diabetic and non-obese patients were included in this study. These patients underwent coronary angiogram (CA) either due to acute coronary syndrome (ACS) or chronic stable angina with positive exercise tests. Results: Our study found a strong association between HOMA-IR and Gensini score (r = 0. 831, with p<0. 001) in general population. The HOMA-IR was the most influential independent predictor for the presence of extensive Coronary atherosclerosis. Nondiabetic and non-obese people carrying the risk of developing the three-vessel disease (3VD) may be identified with a HOMA-IR score of over 5. 9 according to the ROC curve analysis with a sensitivity of 67. 7%. Conclusion: IR that developes in non-diabetic non-obese individuals coincides with more severe and more outspread CAD. In non-diabetic non-obese populations who need a CA, a single HOMA-IR value is higher than 5. 9 may imply an elevated risk for clinically significant CAD. As insulin resistance is a reversible process, risk stratifications of CAD in non-diabetic non-obese populations could include HOMA-IR as one of its parameters.

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APA: Copy

Eid, Mohamed, Sayed, Sherif A., Zaki, Nayel A., Hamdy, Amera M.F., & Altaher, Ali M.A.. (2023). HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in non-diabetic and non-obese patients. CASPIAN JOURNAL OF INTERNAL MEDICINE, 14(3), 495-506. SID. https://sid.ir/paper/1128496/en

Vancouver: Copy

Eid Mohamed, Sayed Sherif A., Zaki Nayel A., Hamdy Amera M.F., Altaher Ali M.A.. HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in non-diabetic and non-obese patients. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2023;14(3):495-506. Available from: https://sid.ir/paper/1128496/en

IEEE: Copy

Mohamed Eid, Sherif A. Sayed, Nayel A. Zaki, Amera M.F. Hamdy, and Ali M.A. Altaher, “HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in non-diabetic and non-obese patients,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 14, no. 3, pp. 495–506, 2023, [Online]. Available: https://sid.ir/paper/1128496/en

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