THE EFFECTIVE CHEMOTHERAPY REGIMEN FOR ADVANCED UNRESECTABLE GASTRIC CANCER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ATARIAN H.; GHADYANI M.; REZVANI HAMID; ABASAHL A.A.GH.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Surgery Year:2007 | Volume:15 | Issue:1 Page(s): 80-86

Download Full-Text

Persian Verion

View:

4,854

Download:

Cites:

Information Journal Paper

Title

THE EFFECTIVE CHEMOTHERAPY REGIMEN FOR ADVANCED UNRESECTABLE GASTRIC CANCER

Author(s)

ATARIAN H. | GHADYANI M. | REZVANI HAMID | ABASAHL A.A.GH. | Issue Writer Certificate

Keywords

ADVANCED GASTRIC CANCERQ4

CHEMOTHERAPYQ3

DOCETAXELQ4

Abstract

Introduction & Objective: In a prospective multicentric phase II trial, we evaluated the efficacy and toxicity of combination of DOCETAXEL, cisplatin and 5fu/lv (DCF) in a group of untreated patients with unresectable advanced and metastatic Gastric Cancer.Materials & Methods: Fifty six patients with locally advanced and metastatic Gastric cancer were enrolled in this study. DOCETAXEL, 75mg/m2 in day 1, Cisplatin 75mg/m2 in day 1, 5-fu 750mg/m2/ for day 1 – 3 with continuous infusion with folinic acid support were administered. The above regimen was given every 3 weeks for total of 6 cycles. The primary end points were time to progression (TTP) and overall survival (OS).Results: In 56 assigned patients (Male = 36, Female = 20) with median age of 56 year, 40% had already undergone unsuccessful laparatomy, a total of 274 cycles of above regimen were given. The average of received cycles was 5 cycles. In 16 months of follow up 75% of patients showed progression, in evaluation after 19 months 65% of patients died and overall survival was 10 months. Until this report 19 out of 56 (35%) were alive for more than a year. Time to progression with DCF was almost two times compared to prior CHEMOTHERAPY regimen. The most important toxicity of this regimen were neutropenic fever in 12% of patients, gastrointestinal toxicity and neuropathy.Conclusions: Adding DOCETAXEL to CF significantly improved RR, TTP, and OS. The above results have associated with brief increase in toxicity, the overall quality of life was better, therefore, DCF regimen could be one of the standard options for patients with untreated ADVANCED GASTRIC CANCERs.

Cites

No record.

References

No record.

Cite

APA: Copy

ATARIAN, H., GHADYANI, M., REZVANI, HAMID, & ABASAHL, A.A.GH.. (2007). THE EFFECTIVE CHEMOTHERAPY REGIMEN FOR ADVANCED UNRESECTABLE GASTRIC CANCER. IRANIAN JOURNAL OF SURGERY, 15(1), 80-86. SID. https://sid.ir/paper/112862/en

Vancouver: Copy

ATARIAN H., GHADYANI M., REZVANI HAMID, ABASAHL A.A.GH.. THE EFFECTIVE CHEMOTHERAPY REGIMEN FOR ADVANCED UNRESECTABLE GASTRIC CANCER. IRANIAN JOURNAL OF SURGERY[Internet]. 2007;15(1):80-86. Available from: https://sid.ir/paper/112862/en

IEEE: Copy

H. ATARIAN, M. GHADYANI, HAMID REZVANI, and A.A.GH. ABASAHL, “THE EFFECTIVE CHEMOTHERAPY REGIMEN FOR ADVANCED UNRESECTABLE GASTRIC CANCER,” IRANIAN JOURNAL OF SURGERY, vol. 15, no. 1, pp. 80–86, 2007, [Online]. Available: https://sid.ir/paper/112862/en

Related Journal Papers