LIFE EXPECTANCY WITH PERIOPERATIVE CHEMOTHERAPY AND CHEMORADIOTHERAPY FOR LOCALLY ADVANCED GASTRIC ADENOCARCINOMA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SADIGHI S.; MOHAGHEGHI S.M.A.; HADAD PEYMAN; OMRANIPOUR R.; MOUSAVI JARAHI S.A.R.; MEMARI F.; RAFAT J.; ABDIRAD AFSHIN; KHATIB SEMNANI R.; SHAHRIARAN SH.; SHAHBAZKHANI B.; KHALILI BOROUJENI N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2008 | Volume:66 | Issue:9 Page(s): 664-669

Download Full-Text

Persian Verion

View:

9,580

Download:

Cites:

Information Journal Paper

Title

LIFE EXPECTANCY WITH PERIOPERATIVE CHEMOTHERAPY AND CHEMORADIOTHERAPY FOR LOCALLY ADVANCED GASTRIC ADENOCARCINOMA

Author(s)

Keywords

CISPLATINQ3

DOCETAXELQ3

GASTRIC CARCINOMAQ3

CHEMORADIOTHERAPYQ3

Abstract

Background: Although postoperative CHEMORADIOTHERAPY should be considered for all patients at high risk for recurrence of adenocarcinoma of the stomach, curative surgery occurs in less than 50% of nonmetastatic gastric cancers. A regimen of DOCETAXEL, CISPLATIN and infusional fluorouracil improves survival of patients with incurable locally-advanced gastric adenocarcinoma. So we assessed the perioperative regimen of DOCETAXEL, CISPLATIN and infusions 5FU (TCF) and postoperative CHEMORADIOTHERAPY to improve outcomes in patients with potentially resectable gastric adenocarcinoma. Methods: Between March 2005 and March 2008, we enrolled 100 patients with stage II to IV (M0) adenocarcinoma of the stomach who had not been treated previously. Treatment consisted of three preoperative and one postoperative cycles of TCF followed by CHEMORADIOTHERAPY. The primary end point was overall survival. The secondary end points were progression-free survival and toxicity of treatment.Results: A total of 100 patients participated, 83 of whom received neoadjuvant and 17 received adjuvant chemotherapy. Seventy-five patients underwent at least D0 gastrectomy. After chemotherapy, tumor stages were significantly lower than before beginning the protocol. Out of 100 patients, 44 had stage IV before chemotherapy versus 15 after the treatment. Three patients showed complete pathologic response. The median survival time was 25 months.Conclusion: DOCETAXEL, CISPLATIN and 5FU combination chemotherapy is an active preoperative treatment in locally advanced gastric cancer. Post operative CHEMORADIOTHERAPY should be considered as an option to lengthen patient survival.

Cites

References

No record.

Cite

APA: Copy

SADIGHI, S., MOHAGHEGHI, S.M.A., HADAD, PEYMAN, OMRANIPOUR, R., MOUSAVI JARAHI, S.A.R., MEMARI, F., RAFAT, J., ABDIRAD, AFSHIN, KHATIB SEMNANI, R., SHAHRIARAN, SH., SHAHBAZKHANI, B., & KHALILI BOROUJENI, N.. (2008). LIFE EXPECTANCY WITH PERIOPERATIVE CHEMOTHERAPY AND CHEMORADIOTHERAPY FOR LOCALLY ADVANCED GASTRIC ADENOCARCINOMA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 66(9), 664-669. SID. https://sid.ir/paper/39179/en

Vancouver: Copy

SADIGHI S., MOHAGHEGHI S.M.A., HADAD PEYMAN, OMRANIPOUR R., MOUSAVI JARAHI S.A.R., MEMARI F., RAFAT J., ABDIRAD AFSHIN, KHATIB SEMNANI R., SHAHRIARAN SH., SHAHBAZKHANI B., KHALILI BOROUJENI N.. LIFE EXPECTANCY WITH PERIOPERATIVE CHEMOTHERAPY AND CHEMORADIOTHERAPY FOR LOCALLY ADVANCED GASTRIC ADENOCARCINOMA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2008;66(9):664-669. Available from: https://sid.ir/paper/39179/en

IEEE: Copy

S. SADIGHI, S.M.A. MOHAGHEGHI, PEYMAN HADAD, R. OMRANIPOUR, S.A.R. MOUSAVI JARAHI, F. MEMARI, J. RAFAT, AFSHIN ABDIRAD, R. KHATIB SEMNANI, SH. SHAHRIARAN, B. SHAHBAZKHANI, and N. KHALILI BOROUJENI, “LIFE EXPECTANCY WITH PERIOPERATIVE CHEMOTHERAPY AND CHEMORADIOTHERAPY FOR LOCALLY ADVANCED GASTRIC ADENOCARCINOMA,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 66, no. 9, pp. 664–669, 2008, [Online]. Available: https://sid.ir/paper/39179/en

Related Journal Papers