ROLE OF SERUM LEVELS OF D-DIMER IN THE EARLY DIAGNOSIS OF ACUTE MESENTERIC ISCHEMIA IN THE RAT

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SHIRANGI S.S.; DAVOUDABADI A.A.H.; AMIRBEIGY M.; MUSAVI GH.A.; VAKILLI Z.

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Journal: Iranian Journal of Surgery Year:2013 | Volume:20 | Issue:4 Page(s): 7-16

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Title

ROLE OF SERUM LEVELS OF D-DIMER IN THE EARLY DIAGNOSIS OF ACUTE MESENTERIC ISCHEMIA IN THE RAT

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ACUTE MESENTERIC ISCHEMIAQ3

D-DIMERQ3

Abstract

Introduction & Objective: The high mortality rate of mesenteric ischaemia is mainly due to delay in diagnosis. For this reason, it is of great importance to find a specific and rapidly elevating marker. In this study we evaluated the role of plasma D-DIMER level in early diagnosis of the ACUTE MESENTERIC ISCHEMIA in rats, caused by ligation of superior mesenteric artery.Materials & Methods: This was a randomized clinical trial. Forty mature male Wistar albino rats wereused in the study. These were divided into four groups, each consisting of ten rats. In group I, after performing a simple laparotomy, blood was sampled at first hour. In group II, after laparotomy the superior mesenteric artery was ligated, and after one hour the blood samples were taken. Group III consisted of rats undergoing a simple laparotomy and blood samples were taken 6 hours later. In group IV blood samples were obtained 6 hours after the ligation of their superior mesenteric artery. Basal D-DIMER levels were determined in the all groups before laparotomy. For the analysis of variables Mann-whitney and wilcoxon methods were used.Results: The plasma D-DIMER level of the ligated groups were significantly higher both at the 1th hour and the 6th hour after ischemia than the level of those who had undergone simple laparotomy (P<0.001). Both Group II (P=0.004) and Group IV (P=0.004) had significantly higher mean D-DIMER level in the first and 6th hour after ischemia compared with the basal level. There was no difference between the levels in Groups II and IV.Conclusions: In rats with ACUTE MESENTERIC ISCHEMIA due to ligation of superior mesenteric artery, plasma D-DIMER level from one hour after ischaemia will increase. This finding suggests that the measurement of the level of the plasma D-DIMER might be a useful tool for the early diagnosis of acute mesenteric obstruction.

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APA: Copy

SHIRANGI, S.S., DAVOUDABADI, A.A.H., AMIRBEIGY, M., MUSAVI, GH.A., & VAKILLI, Z.. (2013). ROLE OF SERUM LEVELS OF D-DIMER IN THE EARLY DIAGNOSIS OF ACUTE MESENTERIC ISCHEMIA IN THE RAT. IRANIAN JOURNAL OF SURGERY, 20(4), 7-16. SID. https://sid.ir/paper/112927/en

Vancouver: Copy

SHIRANGI S.S., DAVOUDABADI A.A.H., AMIRBEIGY M., MUSAVI GH.A., VAKILLI Z.. ROLE OF SERUM LEVELS OF D-DIMER IN THE EARLY DIAGNOSIS OF ACUTE MESENTERIC ISCHEMIA IN THE RAT. IRANIAN JOURNAL OF SURGERY[Internet]. 2013;20(4):7-16. Available from: https://sid.ir/paper/112927/en

IEEE: Copy

S.S. SHIRANGI, A.A.H. DAVOUDABADI, M. AMIRBEIGY, GH.A. MUSAVI, and Z. VAKILLI, “ROLE OF SERUM LEVELS OF D-DIMER IN THE EARLY DIAGNOSIS OF ACUTE MESENTERIC ISCHEMIA IN THE RAT,” IRANIAN JOURNAL OF SURGERY, vol. 20, no. 4, pp. 7–16, 2013, [Online]. Available: https://sid.ir/paper/112927/en

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