Risk factors and lethality associated with Candidemia in severe COVID-19 patients

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Dursun Zehra Bestepe; Sipahioglu Hilal; Yuksel Recep Civan; Sav Hafize; celik ilhami

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Current Medical Mycology Year:2022 | Volume:8 | Issue:1 Page(s): 32-38

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Risk factors and lethality associated with Candidemia in severe COVID-19 patients

Author(s)

Keywords

COVID-19

Candidemia

Intensive care unit

Risk factor

Abstract

Background and Purpose: Candidemia remained important in the Intensive care units (ICU) during the COVID-19 pandemic. This study aimed to investigate the clinical and laboratory data on Candidemia in COVID-19 patients. Materials and Methods: The baseline characteristics, as well as laboratory and clinical findings of Candidemia and non-Candidemia patients, were compared. Candidemia was defined as the isolation of Candida spp. from blood cultures. The isolates were identified by VITEK®,2 (bioMé, rieux, France) commercial method. Antifungal susceptibility was assessed using the E-test method. Univariate and multiple binary logistic regression analyses were performed to compare the variables. Results: In total, 126 patients with the COVID-19 disease were included. Candidemia was diagnosed in 44 (35%) of the patients. The number of patients with diabetes mellitus and chronic renal failure was higher in the Candidemia group. In the Candidemia group, the duration of ICU stay of patients, the 30-day mortality rate, mechanical ventilation therapy, and systemic corticosteroids (Prednisone) usage were significantly higher in Candidemia patients. Moreover, the median white blood cell, neutrophils, and lactate dehydrogenase were higher in the Candidemia group. Univariate and multiple binary logistic regression analyses were performed to compare the variables. Isolated species were identified as Candida albicans (n=12, 41%), Candida parapsilosis (n=7, 24%), Candida glabrata (n=6, 21%), Candida tropicalis (n=3, 10%), and Candida dublinensis (n=1, 3%). In total, three isolates of six C. glabrata species had dose-dependent sensitivity to fluconazole, and one C. parapsilosis was determined to be resistant. Conclusion: The COVID-19 patients who are admitted to ICU have many Risk factors associated with Candidemia. The most common Risk factors for the development of Candidemia were mechanical ventilation, diabetes mellitus, neutrophilia, and low hemoglobin level. The most frequently isolated species was C. albicans. Moreover, caspofungin was found to be the most effective drug in vitro. No significant resistance pattern was detected against the isolated species. It should be noted that risk-stratified antifungal prophylaxis in the ICU is possible.

Multimedia

No record.

Cites

Outcomes of Patients with COVID-19 and Fungal Coinfections: A Systematic Review and Meta-Analysis Study

References

No record.

Cite

APA: Copy

Dursun, Zehra Bestepe, Sipahioglu, Hilal, Yuksel, Recep Civan, Sav, Hafize, & celik, ilhami. (2022). Risk factors and lethality associated with Candidemia in severe COVID-19 patients. CURRENT MEDICAL MYCOLOGY, 8(1), 32-38. SID. https://sid.ir/paper/1130663/en

Vancouver: Copy

Dursun Zehra Bestepe, Sipahioglu Hilal, Yuksel Recep Civan, Sav Hafize, celik ilhami. Risk factors and lethality associated with Candidemia in severe COVID-19 patients. CURRENT MEDICAL MYCOLOGY[Internet]. 2022;8(1):32-38. Available from: https://sid.ir/paper/1130663/en

IEEE: Copy

Zehra Bestepe Dursun, Hilal Sipahioglu, Recep Civan Yuksel, Hafize Sav, and ilhami celik, “Risk factors and lethality associated with Candidemia in severe COVID-19 patients,” CURRENT MEDICAL MYCOLOGY, vol. 8, no. 1, pp. 32–38, 2022, [Online]. Available: https://sid.ir/paper/1130663/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops