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Information Journal Paper

Title

MicroRNAs as Potential Diagnostic New Biomarkers in Diagnosis of Sepsis in Pediatric Patients

Pages

  327-335

Keywords

Systemic inflammatory response syndrome (SIRS) 

Abstract

 Background: Sepsis is one of the most common causes of multiorgan failure. Sepsis requires the presence of infection with a resultant systemic inflammatory state. Organ dysfunction occurs from the combination of the two processes. Sepsis is the main cause of mortality at intensive care units, with 30-50% mortality rate for all septic episodes. MicroRNA (miRNA) profile data could be beneficial as a specific diagnostic biomarker for sepsis and systemic inflammatory response syndrome (SIRS). Methods: Expression of miRNAs-122,-181b,-223 and-146a levels were assayed by quantitative real time polymerase chain reaction (qRT-PCR) in a prospective case control study, where forty septic cases were compared to 40 healthy controls of matched age and gender. Results: miRNAs-122 and-181b were significantly upregulated during early septic conditions, indicating that they could be sensitive and specific biomarkers for diagnosing sepsis. miRNA-223 and miRNA-146a could also represent highly specific and sensitive diagnostic biomarkers, as they were found to be significantly down-regulated. Serum levels of miRNA-223 could be used to predict poor prognosis with 70% sensitivity and 75% specificity, whereas the other three miRNAs could not predict prognosis. Conclusions: Our study shows that all tested miRNAs can be used for early detection of sepsis, with miRNA-223 being predictive of mortality, hence preventing multi-organ failure and reducing mortality, and predicting poor outcomes, thereby assisting in early categorization of ICU patients for rapid appropriate treatment and medico legal aspects.

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    APA: Copy

    Nour, Zeinab, El Hamamsy, Kariman, Ehsan, Iman, Fawaz, Lobna, SHAKER, OLFAT, Mossallam, Dalia, & ElGindy, Hala. (2022). MicroRNAs as Potential Diagnostic New Biomarkers in Diagnosis of Sepsis in Pediatric Patients. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 11(2), 327-335. SID. https://sid.ir/paper/1131679/en

    Vancouver: Copy

    Nour Zeinab, El Hamamsy Kariman, Ehsan Iman, Fawaz Lobna, SHAKER OLFAT, Mossallam Dalia, ElGindy Hala. MicroRNAs as Potential Diagnostic New Biomarkers in Diagnosis of Sepsis in Pediatric Patients. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2022;11(2):327-335. Available from: https://sid.ir/paper/1131679/en

    IEEE: Copy

    Zeinab Nour, Kariman El Hamamsy, Iman Ehsan, Lobna Fawaz, OLFAT SHAKER, Dalia Mossallam, and Hala ElGindy, “MicroRNAs as Potential Diagnostic New Biomarkers in Diagnosis of Sepsis in Pediatric Patients,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 11, no. 2, pp. 327–335, 2022, [Online]. Available: https://sid.ir/paper/1131679/en

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