Association of a Genetic Variant in the Cyclin-Dependent Kinase Inhibitor 2B with Risk of Pancreatic Cancer

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Sardarzadeh Newsha; Khojasteh Leylakoohi Fatemeh; Damavandi Sedigheh; KHALILI TANHA GHAZALEH; Dashtiahangar Mohammad; Khalili Tanha Nima; AVAN AMIR; AMOUEIAN SAKINEH; HASSANIAN SEYED MAHDI; ESMAILY HABIBOLLAH; KHAZAEI MAJID; FERNS GORDON; KHOOEI ALIREZA; ALIAKBARIAN MOHSEN

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Journal: REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY Year:2022 | Volume:11 | Issue:2 Page(s): 336-343

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Title

Association of a Genetic Variant in the Cyclin-Dependent Kinase Inhibitor 2B with Risk of Pancreatic Cancer

Author(s)

Keywords

CDKN2A/B

Rs10811661

Pancreatic cancer

Prognostic biomarker

Abstract

Background: Pancreatic cancer (PC) is among the most aggressive tumors with a poor prognosis, indicating the need for the identification of a novel prognostic biomarker for risk stratifications. Recent genome-wide association studies have demonstrated common genetic variants in a region on chromosome 9p21 associated with an increased risk of different malignancies. Methods: In the present study, we explore the possible relationship between genetic variant, rs10811661, and gene expression of CDKN2B in 75 pancreatic cancer patients, and 188 healthy individuals. DNAs were extracted and genotyping and gene expression were performed by TaqMan real-time PCR and RT-PCR, respectively. Logistic regression was used to assess the association between risk and genotypes, while the significant prognostic variables in the univariate analysis were included in multivariate analyses. Results: The patients with PDAC had a higher frequency of a TT genotype for rs10811661 than the control group. Also, PDAC patients with dominant genetic model, (TT + TC), was associated with increased risk of developing PDAC (OR= 14. 71, 95% CI [1. 96-110. 35], p= 0. 009). Moreover, patients with CC genotype had a higher expression of CDKN2B, in comparison with TT genotype. Conclusions: Our findings demonstrated that CDKN2A/B was associated with the risk of developing PDAC, supporting further investigations in the larger and multicenter setting to validate the potential value of this gene as an emerging marker for PDAC.

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APA: Copy

Sardarzadeh, Newsha, Khojasteh Leylakoohi, Fatemeh, Damavandi, Sedigheh, KHALILI TANHA, GHAZALEH, Dashtiahangar, Mohammad, Khalili Tanha, Nima, AVAN, AMIR, AMOUEIAN, SAKINEH, HASSANIAN, SEYED MAHDI, ESMAILY, HABIBOLLAH, KHAZAEI, MAJID, FERNS, GORDON, KHOOEI, ALIREZA, & ALIAKBARIAN, MOHSEN. (2022). Association of a Genetic Variant in the Cyclin-Dependent Kinase Inhibitor 2B with Risk of Pancreatic Cancer. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 11(2), 336-343. SID. https://sid.ir/paper/1131681/en

Vancouver: Copy

Sardarzadeh Newsha, Khojasteh Leylakoohi Fatemeh, Damavandi Sedigheh, KHALILI TANHA GHAZALEH, Dashtiahangar Mohammad, Khalili Tanha Nima, AVAN AMIR, AMOUEIAN SAKINEH, HASSANIAN SEYED MAHDI, ESMAILY HABIBOLLAH, KHAZAEI MAJID, FERNS GORDON, KHOOEI ALIREZA, ALIAKBARIAN MOHSEN. Association of a Genetic Variant in the Cyclin-Dependent Kinase Inhibitor 2B with Risk of Pancreatic Cancer. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2022;11(2):336-343. Available from: https://sid.ir/paper/1131681/en

IEEE: Copy

Newsha Sardarzadeh, Fatemeh Khojasteh Leylakoohi, Sedigheh Damavandi, GHAZALEH KHALILI TANHA, Mohammad Dashtiahangar, Nima Khalili Tanha, AMIR AVAN, SAKINEH AMOUEIAN, SEYED MAHDI HASSANIAN, HABIBOLLAH ESMAILY, MAJID KHAZAEI, GORDON FERNS, ALIREZA KHOOEI, and MOHSEN ALIAKBARIAN, “Association of a Genetic Variant in the Cyclin-Dependent Kinase Inhibitor 2B with Risk of Pancreatic Cancer,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 11, no. 2, pp. 336–343, 2022, [Online]. Available: https://sid.ir/paper/1131681/en

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