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Information Journal Paper

Title

The effects of St. Thomas I and St. Thomas II Cardioplegia solutions on coronary sinus lactate in mitral valve surgery,A Randomized, Double-blinded, Clinical Trial

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  0-0

Abstract

 Background: Cardiac protection strategies in different methods are challenging and crucial, affecting postoperative morbidity and mortality. Objectives: We compared the cardio-protective effect of two cardioplegia solutions based on Coronary Sinus lactate levels. Methods: This randomized, double-blinded clinical trial study was performed on 46 candidates for Mitral Valve replacement between June 2020 and January 2021. The patients were categorized via block randomization method: 1) St. Thomas I cardioplegia (n=23) and St. Thomas Ⅱ,cardioplegia (n=23). The Coronary Sinus lactate levels at different times were measured. In addition, some intra-operative and clinical characteristics after cardiac surgery were recorded. Data were analyzed in SPSS software (version 26. 0) using paired and independent t-tests, repeated measure ANOVA, and Pearson correlation test at a significance level of P < 0. 05. Results: In the time trend, the lactate levels in patients with St. Thomas Ⅱ,cardioplegia solution had a significantly lower rate than in St. Thomas I (P=0. 001). The two groups displayed no statistical difference between the aortic cross-clamp time (P=0. 069) and the CPB time (P=0. 091). Furthermore, the weaning from mechanical ventilation (P=0. 078) and ICU stay (P=0. 061) demonstrated no statistical difference between the study groups. Conclusion: Based on significantly lower measures of the Coronary Sinus lactate, the St. Thomas Ⅱ,cardioplegia solution showed a better cardio-protective effect in patients undergoing Mitral Valve surgery.

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    APA: Copy

    Arki, Maryam, MOEINIPOUR, ALI ASGHAR, FATHI, MEHDI, Abbasi Teshnizi, Mohammad, Pasandi, Hossein, HEYDARI, MAJID, Kiani Nejad, Akram, Imani Moghaddam, Saeideh, & YAGHUBI, MOHSEN. (2023). The effects of St. Thomas I and St. Thomas II Cardioplegia solutions on coronary sinus lactate in mitral valve surgery,A Randomized, Double-blinded, Clinical Trial. RAZAVI INTERNATIONAL JOURNAL OF MEDICINE, 11(3), 0-0. SID. https://sid.ir/paper/1132080/en

    Vancouver: Copy

    Arki Maryam, MOEINIPOUR ALI ASGHAR, FATHI MEHDI, Abbasi Teshnizi Mohammad, Pasandi Hossein, HEYDARI MAJID, Kiani Nejad Akram, Imani Moghaddam Saeideh, YAGHUBI MOHSEN. The effects of St. Thomas I and St. Thomas II Cardioplegia solutions on coronary sinus lactate in mitral valve surgery,A Randomized, Double-blinded, Clinical Trial. RAZAVI INTERNATIONAL JOURNAL OF MEDICINE[Internet]. 2023;11(3):0-0. Available from: https://sid.ir/paper/1132080/en

    IEEE: Copy

    Maryam Arki, ALI ASGHAR MOEINIPOUR, MEHDI FATHI, Mohammad Abbasi Teshnizi, Hossein Pasandi, MAJID HEYDARI, Akram Kiani Nejad, Saeideh Imani Moghaddam, and MOHSEN YAGHUBI, “The effects of St. Thomas I and St. Thomas II Cardioplegia solutions on coronary sinus lactate in mitral valve surgery,A Randomized, Double-blinded, Clinical Trial,” RAZAVI INTERNATIONAL JOURNAL OF MEDICINE, vol. 11, no. 3, pp. 0–0, 2023, [Online]. Available: https://sid.ir/paper/1132080/en

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