The bFGF Can Improve Angiogenesis in Oral Mucosa and Accelerate Wound Healing

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ZARE REZA; ABDOLSAMADI HAMIDREZA; SOLEIMANI ASL SARA; RADI SHAHRBANOO; BAHRAMI HOSSEIN; JAMSHIDI SHOKOOFEH

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Journal: REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY Year:2023 | Volume:11 | Issue:4 Page(s): 547-552

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Title

The bFGF Can Improve Angiogenesis in Oral Mucosa and Accelerate Wound Healing

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Keywords

bFGF

Healing

Angiogenesis

Wound

Micro Vessel Density

Abstract

Background: The role of the basic fibroblast growth factor (bFGF) has well known in the Angiogenesis and ulcer Healing. In this study, we aimed to evaluate the effects of bFGF on tissue repair in a rat oral mucosal Wound. Methods: Musosal Wound induced on the lip mucosa of rats and bFGF was injected along the edge of the mucosal defect immediately after surgery. The tissues were collected on days 3, 7 and 14 after the Wound induction. The Micro Vessel Density (MVD) and CD34 expression were done by histochemical studies. Results: The bFGF significantly accelerated granulation tissue formation and MVD was increased three days after ulcer induction but decreased 14 days after surgery. The MVD was significantly higher in the bFGF-treated group. The Wound area was decreased in all groups time-dependently and a statistically significant difference (p value? ) was observed between the bFGF-treated group and untreated group. The Wound area was smaller in the bFGF-treated group compared to the untreated group. Conclusions: Our data demonstrated that bFGF can accelerated and facilitated Wound Healing.

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APA: Copy

ZARE, REZA, ABDOLSAMADI, HAMIDREZA, SOLEIMANI ASL, SARA, RADI, SHAHRBANOO, BAHRAMI, HOSSEIN, & JAMSHIDI, SHOKOOFEH. (2023). The bFGF Can Improve Angiogenesis in Oral Mucosa and Accelerate Wound Healing. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 11(4), 547-552. SID. https://sid.ir/paper/1132093/en

Vancouver: Copy

ZARE REZA, ABDOLSAMADI HAMIDREZA, SOLEIMANI ASL SARA, RADI SHAHRBANOO, BAHRAMI HOSSEIN, JAMSHIDI SHOKOOFEH. The bFGF Can Improve Angiogenesis in Oral Mucosa and Accelerate Wound Healing. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2023;11(4):547-552. Available from: https://sid.ir/paper/1132093/en

IEEE: Copy

REZA ZARE, HAMIDREZA ABDOLSAMADI, SARA SOLEIMANI ASL, SHAHRBANOO RADI, HOSSEIN BAHRAMI, and SHOKOOFEH JAMSHIDI, “The bFGF Can Improve Angiogenesis in Oral Mucosa and Accelerate Wound Healing,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 11, no. 4, pp. 547–552, 2023, [Online]. Available: https://sid.ir/paper/1132093/en

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