Impact of Macitentan on the Health-Related Quality of Life in Pulmonary Arterial Hypertension in an Iranian Population

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Shafaghi Shadi; HOSSEIN AHMADI ZARGHAM; keshmiri Mohammad Sadegh; Naghashzadeh Farah; MOHAMADIFAR AREZOO; MALEK MOHAMMAD MAJID; BEHZADNIA NEDA; SALIMINEJAD LEILA; Shadanfar Sharare; Shafaghi Masoud; Aghdasi Sina; Noorali Sima; SHARIF KASHANI BABAK

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Journal Paper

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Journal: Journal of Iranian Medical Council Year:2022 | Volume:5 | Issue:4 Page(s): 712-729

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Title

Impact of Macitentan on the Health-Related Quality of Life in Pulmonary Arterial Hypertension in an Iranian Population

Author(s)

Keywords

Emphasis

Macitentan

Pulmonary hypertension

Quality of life

Abstract

Background: Pulmonary arterial hypertension is a progressive disease of the lung vascular system which causes patients’,functional limitations and reduces their Health-Related Quality of life (HRQoL). This study was aimed at determining the effectiveness of Macitentan on the HRQoL of Iranian PAH patients by the Emphasis 10 questionnaire. Methods: 31 idiopathic class I Pulmonary hypertension patients were enrolled in this cohort study. Patients completed the Emphasis 10 questionnaire at baseline and 6 months after Macitentan consumption. The absolute changes in Emphasis 10 scores were calculated. The effect of Macitentan on functional activity and paraclinical indexes was assessed. Results: The mean Quality of life scores before and after the Macitentan, were 25. 83 (±, 11. 80 SD) and 16. 93 (±, 10. 36 SD), respectively (p-value=0. 001). Besides, administration of Macitentan increased the mean distance in the 6-minute walk test, from 227. 00±, (87. 275 SD) to 263. 67 (±, 115. 855 SD) (p-value=0. 044), led to a reduction in the mean hospitalization days from 2. 23 (±, 4. 049 SD) to 0. 33 (±, 1. 322 SD), (p-value=0. 015) and reduction in times of hospitalization from 0. 57(0. 93) to 0. 10(0. 30), (p-value=0. 017). Although it had a positive effect on mean PAP (81 to 68), O2 saturation at the beginning of 6MW (90 to 91%), final O2 Saturation in 6MW (81 to 85%), and pro-BNP (907 to 412), this effect was not statistically significant. Conclusion: Treatment with Macitentan significantly improved patient functional activity and reduced the mean hospitalization days. Thus, due to the low side effects and high efficacy, it can be advised as the first line of treatment.

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APA: Copy

Shafaghi, Shadi, HOSSEIN AHMADI, ZARGHAM, keshmiri, Mohammad Sadegh, Naghashzadeh, Farah, MOHAMADIFAR, AREZOO, MALEK MOHAMMAD, MAJID, BEHZADNIA, NEDA, SALIMINEJAD, LEILA, Shadanfar, Sharare, Shafaghi, Masoud, Aghdasi, Sina, Noorali, Sima, & SHARIF KASHANI, BABAK. (2022). Impact of Macitentan on the Health-Related Quality of Life in Pulmonary Arterial Hypertension in an Iranian Population. JOURNAL OF IRANIAN MEDICAL COUNCIL, 5(4), 712-729. SID. https://sid.ir/paper/1132463/en

Vancouver: Copy

Shafaghi Shadi, HOSSEIN AHMADI ZARGHAM, keshmiri Mohammad Sadegh, Naghashzadeh Farah, MOHAMADIFAR AREZOO, MALEK MOHAMMAD MAJID, BEHZADNIA NEDA, SALIMINEJAD LEILA, Shadanfar Sharare, Shafaghi Masoud, Aghdasi Sina, Noorali Sima, SHARIF KASHANI BABAK. Impact of Macitentan on the Health-Related Quality of Life in Pulmonary Arterial Hypertension in an Iranian Population. JOURNAL OF IRANIAN MEDICAL COUNCIL[Internet]. 2022;5(4):712-729. Available from: https://sid.ir/paper/1132463/en

IEEE: Copy

Shadi Shafaghi, ZARGHAM HOSSEIN AHMADI, Mohammad Sadegh keshmiri, Farah Naghashzadeh, AREZOO MOHAMADIFAR, MAJID MALEK MOHAMMAD, NEDA BEHZADNIA, LEILA SALIMINEJAD, Sharare Shadanfar, Masoud Shafaghi, Sina Aghdasi, Sima Noorali, and BABAK SHARIF KASHANI, “Impact of Macitentan on the Health-Related Quality of Life in Pulmonary Arterial Hypertension in an Iranian Population,” JOURNAL OF IRANIAN MEDICAL COUNCIL, vol. 5, no. 4, pp. 712–729, 2022, [Online]. Available: https://sid.ir/paper/1132463/en

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