Protective effect of L-carnitine on sperm motility and membrane integrity in men asthenoteratozoospermia: An in vitro study

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Naderi Noreini Samira; Ahmadi Niyatabesh Roya; Malmir Mahdi; Ghafarizadeh Ali Asghar

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Journal: Jorjani Biomedicine Journal Year:621 | Volume: | Issue: Page(s): 19-23

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Title

Protective effect of L-carnitine on sperm motility and membrane integrity in men asthenoteratozoospermia: An in vitro study

Author(s)

Naderi Noreini Samira | Ahmadi Niyatabesh Roya | Malmir Mahdi | Ghafarizadeh Ali Asghar | Issue Writer Certificate

Keywords

L-carnitineQ4

AsthenoteratozoospermiaQ4

Membrane integrityQ4

Sperm parameterQ4

Abstract

Background: Sperm preparation is a time-consuming process that makes a contribution to oxidative stress induction in assisted reproductive techniques. Objective: This study aimed to evaluate the effect of L-carnitine on Sperm parameters during semen preparation at different time intervals. Materials and Methods: In this in vitro study, the semen samples of 50 asthenoteratozoospermic men were divided into the control and the L-carnitine groups (incubated with 0. 5 mg/mL L-carnitine) (n=25/each). Total motility, progressive motility, sperm Membrane integrity (by Hypo-osmotic swelling test), and lipid peroxidation (by Malondialdehyde level) were assessed in each group after 2, 4, and 6 hours. Afterward, samples were analyzed by the World Health Organization (2010) criteria. Result: The results showed that in the control group total and progressive motility, and Membrane integrity of the sperm were significantly decreased after 2 hr (P= 0. 028, p= 0. 019, and p= 0. 025, respectively), while Malondialdehyde levels increased significantly after 4 hr (P= 0. 018). Sperm parameters in the L-carnitine group increased significantly after 2 hr (P= 0. 002), while Malondialdehyde levels decreased significantly compared to the control group in 6 hr (P < 0. 001 vs. P =0. 045). Conclusion: Based on these results, L-carnitine can manage to conserve motility and sperm Membrane integrity of sperm from the hazardous impact of oxidative stress and lipid peroxidation during sperm preparation.

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