THE EFFECT OF CENTRAL AMYGDALA NITRIC OXIDE IN EXPRESSION OF DRUG SEEKING BEHAVIORS

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RAHIMPOUR M.; KARAMI M.; JALALI M.R.N.

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Journal: RESEARCH ON ADDICTION Year:2011 | Volume:5 | Issue:19 Page(s): 101-115

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Title

THE EFFECT OF CENTRAL AMYGDALA NITRIC OXIDE IN EXPRESSION OF DRUG SEEKING BEHAVIORS

Author(s)

RAHIMPOUR M. | KARAMI M. | JALALI M.R.N. | Issue Writer Certificate

Keywords

MORPHINEQ2

NITRIC OXIDEQ2

CENTRAL AMYGDALEQ2

L-ARGININEQ2

L-NAMEQ2

DRUG SEEKING BEHAVIORQ2

Abstract

Introduction: Previous studies shows L-arginin (nitric oxide precursor) increases conditioned place preference and DRUG SEEKING BEHAVIORs whereas LG-nitro-arginine methyl ester (L-NAME) as NITRIC OXIDE synthase inhibitor decreases this process. In this project, effects of intra-central amygdale bilateral injection of NITRIC OXIDE agents on drug-seeking behaviors including rearing, sniffing and compartment entrance were investigated.Method: animals were wistar male rats (200-250 g) which allowed to be recovered after they’re being suffered from a surgery by strereotaxis apparatus to be cannulated in coordination of CENTRAL AMYGDALE nucleus (CeA). CPP was conducted using a five-day schedule of unbiased procedure.Findings: MORPHINE (2.5-10 mg/kg s.c) induced significant drug-seeking behaviors. Naloxone (0.1-0.4 mg/kg i.p) injection pretesting (after conditioning by MORPHINE 7.5 mg/kg) decreased the expression of behaviors. When L-ARGININE (0.3-3 mgr/rat) injected intra-CeA prior to naloxone (0.4 mg/kg), increased behaviors but L-NAME (0.3-3mgr/rat) intra-CeA injections prior to L-ARGININE (0.3 mgr/rat) pretesting, caused significant decreasement of L-ARGININE response.Conclusion: NO in the CeA may play an important role in the DRUG SEEKING BEHAVIORs induced of MORPHINE.

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APA: Copy

RAHIMPOUR, M., KARAMI, M., & JALALI, M.R.N.. (2011). THE EFFECT OF CENTRAL AMYGDALA NITRIC OXIDE IN EXPRESSION OF DRUG SEEKING BEHAVIORS. RESEARCH ON ADDICTION, 5(19), 101-115. SID. https://sid.ir/paper/113879/en

Vancouver: Copy

RAHIMPOUR M., KARAMI M., JALALI M.R.N.. THE EFFECT OF CENTRAL AMYGDALA NITRIC OXIDE IN EXPRESSION OF DRUG SEEKING BEHAVIORS. RESEARCH ON ADDICTION[Internet]. 2011;5(19):101-115. Available from: https://sid.ir/paper/113879/en

IEEE: Copy

M. RAHIMPOUR, M. KARAMI, and M.R.N. JALALI, “THE EFFECT OF CENTRAL AMYGDALA NITRIC OXIDE IN EXPRESSION OF DRUG SEEKING BEHAVIORS,” RESEARCH ON ADDICTION, vol. 5, no. 19, pp. 101–115, 2011, [Online]. Available: https://sid.ir/paper/113879/en

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