مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Estrogen Receptor Alpha Gene (ESR1) Facilitates Th2-immune Response and Enhances Th2 Cytokines in Experimental Atopic Dermatitis Mice

Pages

  167-176

Abstract

 Background: Molecular markers are involved in Atopic Dermatitis (AD) pathogenesis. The estrogen receptor (ESR)-1 gene, encoding ERα, , is reported to express aberrantly in AD patients. Objective: To detect the biological functions of ESR1 in 2, 4 dinitrochlorobenzene (DNCB)-treated Mice. Methods: The DNCB-treated Mice received a topical application of emulsion containing the 1, 3-bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinyl ethoxy) phenol]-1H-pyrazole dihydrochloride (MPP,an ESR1-selective Antagonist) to dorsal skins and ears. Then the dermatitis scores, histopathological changes, and cytokine levels were evaluated. Results: MPP specifically downregulated ESR1 expression in DNCB-applied Mice. Functionally, application of MPP abolished the DNCB-induced promotion in dermatitis score. Additionally, MPP administration protected against DNCB-induced dermatitis severity, suppressed mast cell infiltration and reduced production of immunoglobulin E (IgE) and thymus and activation-regulated chemokine (TARC). Moreover, MPP treatment inhibited DNCB nduced production of Th2 cytokines and infiltration of CD4+ T cells. Conclusion: ESR1 facilitates Th2-immune response and enhances Th2 cytokines in AD Mice.

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    APA: Copy

    Niu, Jianrong, ZHOU, HUI, Tian, Rong, & Wang, Xudong. (2023). Estrogen Receptor Alpha Gene (ESR1) Facilitates Th2-immune Response and Enhances Th2 Cytokines in Experimental Atopic Dermatitis Mice. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 20(2), 167-176. SID. https://sid.ir/paper/1145601/en

    Vancouver: Copy

    Niu Jianrong, ZHOU HUI, Tian Rong, Wang Xudong. Estrogen Receptor Alpha Gene (ESR1) Facilitates Th2-immune Response and Enhances Th2 Cytokines in Experimental Atopic Dermatitis Mice. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2023;20(2):167-176. Available from: https://sid.ir/paper/1145601/en

    IEEE: Copy

    Jianrong Niu, HUI ZHOU, Rong Tian, and Xudong Wang, “Estrogen Receptor Alpha Gene (ESR1) Facilitates Th2-immune Response and Enhances Th2 Cytokines in Experimental Atopic Dermatitis Mice,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 20, no. 2, pp. 167–176, 2023, [Online]. Available: https://sid.ir/paper/1145601/en

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