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Information Journal Paper

Title

The Upregulation of HLA-G1 and miRNA-34a in Lens Epithelial Cells of Diabetic Retinopathy Patients

Pages

  202-210

Abstract

 Background: Retinopathy of diabetes is a chronic diabetes mellitus complication affecting retinal vessels, and some ocular complications’,molecular mechanisms remain obscure. Objective: To evaluate the expression of HLA-G1, HLA-G5, miRNA-181a, and miRNA-34a in the Lens Epithelial Cells of patients with retinopathy of diabetes. Methods: In a case-control study, 30 diabetic patients with retinopathy, 30 diabetic patients without retinopathy, and 30 cataract patients without diabetes mellitus as the control group were enrolled after a full description with details about the study methods and objectives. The expression of HLA G1, HLA-G5, miRNA-181a, and miRNA-34a in Lens Epithelial Cells was assessed by quantitative RT PCR. Moreover, the levels of HLA-G protein in aqueous humor were evaluated by the ELISA method. Results: HLA-G1 expression was significantly upregulated in the retinopathy group (P=0. 003). The aqueous humor of Diabetic Retinopathy patients contained significantly higher levels of HLA-G protein compared with the non-diabetic patients (P=0. 001). miRNA 181a was significantly downregulated in the Diabetic Retinopathy group compared with the patients without diabetes (P=0. 001). In addition, miRNA-34a was upregulated in the retinopathy group (P=0. 009). Conclusion: Taken together, the present results showed that HLA-G1 and miRNA-34a can be valuable markers for Diabetic Retinopathy. Our data offers new perspectives for improving the control of inflammation in the Lens Epithelial Cells by considering HLA-G and miRNA.

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    APA: Copy

    Taghvaei Bijandi, Elnaz, Abedian, Fatemeh, AHMADZADEH AMIRI, AHMAD, JAFARI, NARJES, & ABEDIANKENARI, SAEID. (2023). The Upregulation of HLA-G1 and miRNA-34a in Lens Epithelial Cells of Diabetic Retinopathy Patients. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 20(2), 202-210. SID. https://sid.ir/paper/1145604/en

    Vancouver: Copy

    Taghvaei Bijandi Elnaz, Abedian Fatemeh, AHMADZADEH AMIRI AHMAD, JAFARI NARJES, ABEDIANKENARI SAEID. The Upregulation of HLA-G1 and miRNA-34a in Lens Epithelial Cells of Diabetic Retinopathy Patients. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2023;20(2):202-210. Available from: https://sid.ir/paper/1145604/en

    IEEE: Copy

    Elnaz Taghvaei Bijandi, Fatemeh Abedian, AHMAD AHMADZADEH AMIRI, NARJES JAFARI, and SAEID ABEDIANKENARI, “The Upregulation of HLA-G1 and miRNA-34a in Lens Epithelial Cells of Diabetic Retinopathy Patients,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 20, no. 2, pp. 202–210, 2023, [Online]. Available: https://sid.ir/paper/1145604/en

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