Senescent CD153 + T Lymphocytes Increase in the Peripheral Blood of Patients with Thromboangiitis Obliterans

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Mashhadi Niloofar; Kasraian Leila; Ghoddusi Johari Hamed; Hoseinzadeh Ahmad; Kheshtchin Nasim; DOROUDCHI MEHRNOOSH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Immunology Year:2023 | Volume:20 | Issue:3 Page(s): 262-275

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Senescent CD153 + T Lymphocytes Increase in the Peripheral Blood of Patients with Thromboangiitis Obliterans

Author(s)

Keywords

CD57

CD153/CD30L

Cigarette Smoking

Immunosenescence

Thromboangiitis Obliterans

Abstract

Background: Buerger’, s disease, also known as Thromboangiitis Obliterans (TAO), is a progressive, inflammatory vascular disease with unknown etiology. Objective: To address the degree of T cell Immunosenescence in this inflammatory disease, the frequency of senescent T cells expressing CD57 and/or CD153 (CD30L) in patients with TAO. Methods: In this study, nine male cigarette smoker patients with TAO, nine male healthy cigarette smokers, and nine male healthy nonsmoker blood donors were enrolled. PBMCs were extracted from the blood of all participants and stored in liquid nitrogen before use. The percentages of senescent T cells were detected by flow cytometry. The results were analyzed using non-parametric statistical tests. Results: The frequencies of senescent CD3+ CD4 + CD57 + CD153 + and CD3 + CD4 + CD57-CD153 + T cells significantly increased in patients compared with the non-smoker controls (p=0. 01 and p=0. 04, respectively). The frequency of senescent CD3 + CD4-CD57-CD153+ T cells was higher in patients compared with the smoker controls (p= 0. 02). I n patients with TAO, CD57 + CD153- cells were more f requent in CD3 hi CD4- and CD3 hi CD4 + T cells compared with the CD3 lo CD4- and CD3 lo CD4 + T cells (p=0. 008 and p=0. 0002, respectively). Conversely, the frequency of CD57-CD153 + T cells was significantly higher in CD3 lo CD4- T cells compared with the CD3 hi CD4- T cells (p=0. 004). The percentage of CD3 + CD4 + CD57 + CD153- T cells correlated negatively with smoking level in smoker controls (p=0. 02, Spearman r=-0. 80). Conclusion: Elevated frequencies of senescent CD4 + CD57 + CD153 + and CD4 + CD57-CD153 + T cells in patients compared with non-smoker and smoker controls suggest the contribution of Immunosenescence in TAO.

Cites

No record.

References

No record.

Cite

APA: Copy

Mashhadi, Niloofar, Kasraian, Leila, Ghoddusi Johari, Hamed, Hoseinzadeh, Ahmad, Kheshtchin, Nasim, & DOROUDCHI, MEHRNOOSH. (2023). Senescent CD153 + T Lymphocytes Increase in the Peripheral Blood of Patients with Thromboangiitis Obliterans. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 20(3), 262-275. SID. https://sid.ir/paper/1145610/en

Vancouver: Copy

Mashhadi Niloofar, Kasraian Leila, Ghoddusi Johari Hamed, Hoseinzadeh Ahmad, Kheshtchin Nasim, DOROUDCHI MEHRNOOSH. Senescent CD153 + T Lymphocytes Increase in the Peripheral Blood of Patients with Thromboangiitis Obliterans. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2023;20(3):262-275. Available from: https://sid.ir/paper/1145610/en

IEEE: Copy

Niloofar Mashhadi, Leila Kasraian, Hamed Ghoddusi Johari, Ahmad Hoseinzadeh, Nasim Kheshtchin, and MEHRNOOSH DOROUDCHI, “Senescent CD153 + T Lymphocytes Increase in the Peripheral Blood of Patients with Thromboangiitis Obliterans,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 20, no. 3, pp. 262–275, 2023, [Online]. Available: https://sid.ir/paper/1145610/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops