Neutrophil Extracellular Traps Formation and Citrullinated Histones 3 Levels in Patients with Kawasaki Disease

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HU JING; Qian Wei; Wang Tianhe; Ling Jingjing; Shi Yingzuo

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Immunology Year:2023 | Volume:20 | Issue:3 Page(s): 327-334

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Neutrophil Extracellular Traps Formation and Citrullinated Histones 3 Levels in Patients with Kawasaki Disease

Author(s)

Keywords

Citrullinated Histone 3

IVIG

Kawsaki Disease

Neutrophil Extracellular Traps

Abstract

Background: Kawasaki disease (KD) is a vasculitis associated with vascular injury and autoimmune response. Inflammatory factors stimulate neutrophils to produce web-like structures called Neutrophil Extracellular Traps (NETs). Citrullinated Histone 3 (H3Cit) is one of the main protein components of Neutrophil Extracellular Traps involved in the process of NETosis. The levels of NETs and H3Cit in the KD are not known. Objective: To determine the changes in the levels of NETs and H3Cit in KD. Methods: Children with KD were recruited and divided into the acute KD and the sub-acute KD group according to the disease phase and whether intravenous immunoglobulin (IVIG) was used or not. Peripheral venous blood was taken before and after the IVIG administration and sent for the examination of NETs by flow cytometry. The level of H3Cit was measured by enzyme-linked immunosorbent assay (ELISA). Results: The counts of NETs in the acute KD group significantly increased compared with the healthy controls (p<0. 01). The level of H3Cit was significantly higher in the acute KD group than in the healthy control subjects. Of note, both the counts of NETs and the level of H3Cit decreased in the KD patients treated with IVIG compared with the acute KD group (p<0. 01). Conclusion: Acute KD is characterized by an increased formation of NETs and high levels of H3Cit. IVIG significantly inhibited NETs formation and also reduced the level of plasma H3Cit in children with KD.

Cites

No record.

References

No record.

Cite

APA: Copy

HU, JING, Qian, Wei, Wang, Tianhe, Ling, Jingjing, & Shi, Yingzuo. (2023). Neutrophil Extracellular Traps Formation and Citrullinated Histones 3 Levels in Patients with Kawasaki Disease. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 20(3), 327-334. SID. https://sid.ir/paper/1145615/en

Vancouver: Copy

HU JING, Qian Wei, Wang Tianhe, Ling Jingjing, Shi Yingzuo. Neutrophil Extracellular Traps Formation and Citrullinated Histones 3 Levels in Patients with Kawasaki Disease. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2023;20(3):327-334. Available from: https://sid.ir/paper/1145615/en

IEEE: Copy

JING HU, Wei Qian, Tianhe Wang, Jingjing Ling, and Yingzuo Shi, “Neutrophil Extracellular Traps Formation and Citrullinated Histones 3 Levels in Patients with Kawasaki Disease,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 20, no. 3, pp. 327–334, 2023, [Online]. Available: https://sid.ir/paper/1145615/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops