Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease

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Zangeneh Zivar; KHAMISIPOUR GHOLAMREZA

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Journal Paper

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Journal: Iranian Journal of Immunology Year:2023 | Volume:20 | Issue:3 Page(s): 368-373

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Information Journal Paper

Title

Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease

Author(s)

Zangeneh Zivar | KHAMISIPOUR GHOLAMREZA | Issue Writer Certificate

Keywords

COVID-19

C-Reactive Protein

Heat Shock Proteins

Inflammation

Pulmonary

Abstract

Background: Heat Shock Proteins (HSPs) are involved in innate and adaptive immune responses, especially inflammatory responses due to immune cell activation. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was one of the most important causes of death in the recent pandemic. Increased cellular stress and excessive Inflammation are common in coronavirus disease-19 (COVID-19), although the underlying mechanisms are still poorly understood. Objective: To evaluate the relationship between HSP and the pathological effects of COVID-19. Methods: A group of 107 patients was categorized to two populations (mild and severe) based on their chest high-resolution computed tomography (HRCT) results. The HSP70, HSP90 alpha, and serum levels of C-Reactive Protein (CRP) were measured by enzymelinked immunosorbent assay (ELISA). Lactate dehydrogenase (LDH), and creatine phosphokinase (CPK) were measured by the automated analyzer. Results: Our data showed increased levels of HSP70 and HSP90 in patients with COVID-19. The HSPs levels were elevated in the severe group compared to the mild group. This study demonstrated a positive correlation between both elevated levels of HSP70, HSP90, and HRCT grade and also a positive correlation with CRP and CPK in the severe group. Conclusion: HSP90 and HSP70 contribute to excessive immune responses and cytokine storms. They may serve as prognostic serum markers for COVID-19 lung injury. Additionally, they are candidates for anti-inflammatory therapy.

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APA: Copy

Zangeneh, Zivar, & KHAMISIPOUR, GHOLAMREZA. (2023). Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 20(3), 368-373. SID. https://sid.ir/paper/1145619/en

Vancouver: Copy

Zangeneh Zivar, KHAMISIPOUR GHOLAMREZA. Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2023;20(3):368-373. Available from: https://sid.ir/paper/1145619/en

IEEE: Copy

Zivar Zangeneh, and GHOLAMREZA KHAMISIPOUR, “Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 20, no. 3, pp. 368–373, 2023, [Online]. Available: https://sid.ir/paper/1145619/en

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