Prevention of glycerol-induced acute kidney injury by isoflurane inhalation in male rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Givechian Negin; Ashabi Ghorbangol; Kadkhodaee Mehri; Seif Behjat; Abdi Arash; Kianian Farzaneh; Kianfar Tina

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2024 | Volume:28 | Issue:2 Page(s): 91-98

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Prevention of glycerol-induced acute kidney injury by isoflurane inhalation in male rats

Author(s)

Keywords

GlycerolQ4

Blood Urea NitrogenQ4

CreatinineQ4

IsofluraneQ4

KidneyQ4

Abstract

Introduction: Acute Kidney injury (AKI) is a severe complication of rhabdomyolysis (RM), where skeletal muscle injury leads to the release of cell contents into the bloodstream, ultimately obstructing renal tubules. This results in renal dysfunction due to increased oxidative stress, inflammation, and apoptosis. Glycerol (10 mL/kg) injection is one of the most common methods to induce experimental AKI,but 10 mL/kg dosage seems to be harmful to rats because we have observed some side effects. This study was designed to evaluate the effects of Isoflurane pretreatment in the Glycerol model of acute Kidney injury, but at first we tried to find a better dosage of Glycerol to induce AKI less harmful. Methods: 28 male Wistar rats were used in our investigation. We first studied to find the most effective dosage of Glycerol for AKI induction in three groups (5, 6. 25, and 10 mL/kg), and accordingly 6. 25 mL/kg was selected. Secondly, we investigated Isoflurane (1. 5%, 20 minutes) pretreatment effects on Glycerol-induced AKI by estimating Blood Urea Nitrogen (BUN), Creatinine (Cr), Bax/Bcl-2 proteins ratio (Bcl-2-associated X/B-cell lymphoma 2), malondialdehyde (MDA), superoxide dismutase (SOD), and histological changes in renal tissues. Results: The results showed that Isoflurane pretreatment suppressed oxidative stress and apoptosis, and therefore was able to improve renal function. Conclusion: Isoflurane pretreatment might be protective against rhabdomyolysis-induced AKI because of its anti-oxidant and anti-apoptotic activities.

Cites

No record.

References

No record.

Cite

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops