ANTIOXIDANT EFFECTS OF L-SERINE AGAINST FATTY STREAK FORMATION IN HYPERCHOLESTEROLEMIC ANIMALS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOVAHEDIAN A.; NADERI GH.A.; DASHTI GH.R.; ASGARI SEDIGHEH; ZAD HOUSH F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ARYA Atherosclerosis Year:2006 | Volume:2 | Issue:3 (7) Page(s): 126-129

Download Full-Text

Persian Verion

View:

852

Download:

168

Cites:

Information Journal Paper

Title

ANTIOXIDANT EFFECTS OF L-SERINE AGAINST FATTY STREAK FORMATION IN HYPERCHOLESTEROLEMIC ANIMALS

Author(s)

Keywords

ATHEROSCLEROSISQ4

CHOLESTEROLQ3

L-SERINEQ4

ANTIOXIDANTQ4

LIPIDSQ4

FATTY STREAKQ4

Abstract

INTRODUCTION: Peroxidation of blood lipoproteins is regarded as a key event in the development of ATHEROSCLEROSIS. Evidence suggests that oxidative modification of amino acids in low-density lipoprotein (LDL) particles leads to its convert into an atherogenic form, which is taken up by macrophages. Therefore the reduction of oxidative modification of lipoproteins by increasing plasma ANTIOXIDANT capacity may prevent cardiovascular disease.METHODS: In this study, the ANTIOXIDANT and anti-fatty streak effects of L-SERINE were investigated in hypercholesterolemic rabbits. Rabbits were randomly divided into three groups which were fed high-cholesterol diet (hypercholesterolemic control group), highcholesterol + L-SERINE diet (treatment group), and normal diet (control) for twelve weeks and then blood samples were obtained to measure plasma CHOLESTEROL, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), ANTIOXIDANT capacity (AC), malondialdehyde (MDA), and conjugated dienes (CDS). Right and left coronary arteries were also obtained for histological evaluation.RESULTS: No significant difference was observed in plasma CHOLESTEROL, TG, HDL, LDL and CDS levels between treatment and hypercholesterolemic control groups (P>0.05).The levels of plasma MDA and AC were 0.29 μM and 56%, respectively in the treatment group which showed a significant change in comparison with hypercholesterolemic control groups (P<0.05). The mean size of produced FATTY STREAK also showed significant reduction in the treatment group compared to the hypercholesterolemic group (P<0.05).CONCLUSIONS: The results showed that L-SERINE has ANTIOXIDANT and anti-fatty streak effects without any influence on plasma lipid levels in hypercholesterolemic rabbits.

Cites

No record.

References

No record.

Cite

APA: Copy

MOVAHEDIAN, A., NADERI, GH.A., DASHTI, GH.R., ASGARI, SEDIGHEH, & ZAD HOUSH, F.. (2006). ANTIOXIDANT EFFECTS OF L-SERINE AGAINST FATTY STREAK FORMATION IN HYPERCHOLESTEROLEMIC ANIMALS. ARYA ATHEROSCLEROSIS, 2(3 (7)), 126-129. SID. https://sid.ir/paper/117027/en

Vancouver: Copy

MOVAHEDIAN A., NADERI GH.A., DASHTI GH.R., ASGARI SEDIGHEH, ZAD HOUSH F.. ANTIOXIDANT EFFECTS OF L-SERINE AGAINST FATTY STREAK FORMATION IN HYPERCHOLESTEROLEMIC ANIMALS. ARYA ATHEROSCLEROSIS[Internet]. 2006;2(3 (7)):126-129. Available from: https://sid.ir/paper/117027/en

IEEE: Copy

A. MOVAHEDIAN, GH.A. NADERI, GH.R. DASHTI, SEDIGHEH ASGARI, and F. ZAD HOUSH, “ANTIOXIDANT EFFECTS OF L-SERINE AGAINST FATTY STREAK FORMATION IN HYPERCHOLESTEROLEMIC ANIMALS,” ARYA ATHEROSCLEROSIS, vol. 2, no. 3 (7), pp. 126–129, 2006, [Online]. Available: https://sid.ir/paper/117027/en

Related Journal Papers