THE EFFECT OF LOW-DOSE KETAMINE INFUSION ON HEMODYNAMIC CHANGE IN CORONARY ARTERY BYPASS GRAFT SURGERY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AKHLAGH S.H.A.; ZEIGHAMI D.; ALLAHYARY E.; MAGHSOODI B.; AZEMATI S.; ALIPOUR A.; HADAVI S.M.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Epidemiology Year:2010 | Volume:6 | Issue:2 Page(s): 48-55

Download Full-Text

Persian Verion

View:

633

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF LOW-DOSE KETAMINE INFUSION ON HEMODYNAMIC CHANGE IN CORONARY ARTERY BYPASS GRAFT SURGERY

Author(s)

Keywords

KETAMINEQ3

HEMODYNAMIC CHANGEQ2

CORONARY ARTERY SURGERYQ3

LACTATEQ2

PERFUSIONQ3

Abstract

Background & objectives: Cardiopulmonary bypass often causes a stress hormonal response with subsequent changes in hemodynamic and organ PERFUSION. Human studies involving cardiopulmonary bypass have shown that very low doses of KETAMINE can attenuate inflammatory and stress markers, without adverse effects. The aim of this study was to investigate whether low dose infusion of KETAMINE have hemodynamic stability effect in coronary artery bypass surgery.Methods: In this double blind-controlled trial, 50 patients undergoing on-pump CABG were randomly assigned to receive either 1.25mcg/kg/min of KETAMINE infusion (KETAMINE group, n=25) or normal saline infusion (Control group, n=25) during 48 hours after induction of anesthesia. hemodynamic measurement including blood pressure, heart rate, central venous pressure, cardiac output, cardiac index, systemic venous resistance, arterial blood gas and LACTATE were measured previous to induction (T1), 4 h, 24h, and 48h after the surgery (T2, T3 and T4). The data were evaluated with using of variance analyzing test and repeated measurement.Results: There were significant interaction effect between time (pre operation, 4, 24 and 48 hours after operation) and group of study (KETAMINE and placebo) in assessment of systolic blood pressure (p=0.0001), diastolic blood pressure(p=0.0001), heart rate (p=0.004), central venous pressure (p=0.0001) and LACTATE (p=0.035). These indicate that KETAMINE caused decrement in tissue PERFUSION. Those interactions were not statistically significant for other parameters (p>0.05).Conclusions: low dose KETAMINE during and 48 hours after operation not only didn't show hemodynamic stability effect but also decreased tissue PERFUSION slightly.

Cites

No record.

References

Cite

APA: Copy

AKHLAGH, S.H.A., ZEIGHAMI, D., ALLAHYARY, E., MAGHSOODI, B., AZEMATI, S., ALIPOUR, A., & HADAVI, S.M.R.. (2010). THE EFFECT OF LOW-DOSE KETAMINE INFUSION ON HEMODYNAMIC CHANGE IN CORONARY ARTERY BYPASS GRAFT SURGERY. IRANIAN JOURNAL OF EPIDEMIOLOGY, 6(2), 48-55. SID. https://sid.ir/paper/120491/en

Vancouver: Copy

AKHLAGH S.H.A., ZEIGHAMI D., ALLAHYARY E., MAGHSOODI B., AZEMATI S., ALIPOUR A., HADAVI S.M.R.. THE EFFECT OF LOW-DOSE KETAMINE INFUSION ON HEMODYNAMIC CHANGE IN CORONARY ARTERY BYPASS GRAFT SURGERY. IRANIAN JOURNAL OF EPIDEMIOLOGY[Internet]. 2010;6(2):48-55. Available from: https://sid.ir/paper/120491/en

IEEE: Copy

S.H.A. AKHLAGH, D. ZEIGHAMI, E. ALLAHYARY, B. MAGHSOODI, S. AZEMATI, A. ALIPOUR, and S.M.R. HADAVI, “THE EFFECT OF LOW-DOSE KETAMINE INFUSION ON HEMODYNAMIC CHANGE IN CORONARY ARTERY BYPASS GRAFT SURGERY,” IRANIAN JOURNAL OF EPIDEMIOLOGY, vol. 6, no. 2, pp. 48–55, 2010, [Online]. Available: https://sid.ir/paper/120491/en

Related Journal Papers