THE EFFECT OF CREATINE MONOHYDRATE SUPPLEMENTATION ON APOPTOSIS AT ACUTE RESISTANCE EXERCISE IN MIDDLE-AGED MEN

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SARI SARRAF V.; AMIRSASAN R.; SHEIKHOLESLAMI VATANI D.; FARAJI H.

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Journal: JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY Year:2017 | Volume:11 | Issue:4 Page(s): 47-54

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Title

THE EFFECT OF CREATINE MONOHYDRATE SUPPLEMENTATION ON APOPTOSIS AT ACUTE RESISTANCE EXERCISE IN MIDDLE-AGED MEN

Author(s)

SARI SARRAF V. | AMIRSASAN R. | SHEIKHOLESLAMI VATANI D. | FARAJI H. | Issue Writer Certificate

Keywords

APOPTOSISQ2

CREATINE MONOHYDRATEQ2

CASPASE 8Q2

P53Q2

RESISTANCE EXERCISEQ2

Abstract

Background and Objectives: The effect of CREATINE MONOHYDRATE loading on exercise-induced APOPTOSIS is unclear. The purpose of this study was to examine the effect of creatine supplementation on APOPTOSIS at acute RESISTANCE EXERCISE in men.Materials and Methods: In a randomized, placebo controlled, clinical trial study, twenty 42-49 middle-aged year men were randomly assigned to supplement with 20 g per day of CREATINE MONOHYDRATE or placebo (maltodextrin) similarly for one week. On the 8th day, the subjects performed an acute RESISTANCE EXERCISE with 80% of one repetition maximum. Blood samples were collected a day before supplementation loading (Pre) and immediately post-acute exercise (Post) for the measurement of serum P53, CASPASE 8 and Insulinlike growth factor 1 (IGF-1) concentrations. Data were analyzed by Student’s paired and unpairedt tests at the significant level of P<0.05.Results: P53 serum [Pre: 486.41±40.98, Post: 842.20±170.86 ng/L (p=.000)] and CASPASE 8 [Pre=8.36±1.26, Post: 11.66±4.15 ng/ml (p=.031)] levels were significantly increased in the placebo group immediately postacute exercise. Also IGF-1 was significantly increased in both groups. The P53 level was significantly higher in the placebo group as compared to the creatine group immediately post-acute exercise (P<0.05).Conclusion: The results indicated that CREATINE MONOHYDRATE loading can inhibit acute resistance-induced APOPTOSIS in middle-aged. Thus, one week creatine supplementation may be a useful strategy for preventing APOPTOSIS by extensive acute exercise.

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APA: Copy

SARI SARRAF, V., AMIRSASAN, R., SHEIKHOLESLAMI VATANI, D., & FARAJI, H.. (2017). THE EFFECT OF CREATINE MONOHYDRATE SUPPLEMENTATION ON APOPTOSIS AT ACUTE RESISTANCE EXERCISE IN MIDDLE-AGED MEN. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, 11(4), 47-54. SID. https://sid.ir/paper/121535/en

Vancouver: Copy

SARI SARRAF V., AMIRSASAN R., SHEIKHOLESLAMI VATANI D., FARAJI H.. THE EFFECT OF CREATINE MONOHYDRATE SUPPLEMENTATION ON APOPTOSIS AT ACUTE RESISTANCE EXERCISE IN MIDDLE-AGED MEN. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY[Internet]. 2017;11(4):47-54. Available from: https://sid.ir/paper/121535/en

IEEE: Copy

V. SARI SARRAF, R. AMIRSASAN, D. SHEIKHOLESLAMI VATANI, and H. FARAJI, “THE EFFECT OF CREATINE MONOHYDRATE SUPPLEMENTATION ON APOPTOSIS AT ACUTE RESISTANCE EXERCISE IN MIDDLE-AGED MEN,” JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, vol. 11, no. 4, pp. 47–54, 2017, [Online]. Available: https://sid.ir/paper/121535/en

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