A STUDY OF L-ARGININE TO ASYMMETRIC DIMETHYLARGININE RATIO IN MIDDLE AGED HYPERTENSIVE MEN AND EFFECT OF AEROBIC TRAINING ON THIS VARIABLE

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shabaaninia Maysam; SHAHIDI FERESHTEH; RAJABI HAMID; NAZARI IRAJ

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Journal: Jundishapur Scientific Medical Journal Year:2016 | Volume:15 | Issue:6 Page(s): 745-756

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Title

A STUDY OF L-ARGININE TO ASYMMETRIC DIMETHYLARGININE RATIO IN MIDDLE AGED HYPERTENSIVE MEN AND EFFECT OF AEROBIC TRAINING ON THIS VARIABLE

Author(s)

shabaaninia Maysam | SHAHIDI FERESHTEH | RAJABI HAMID | NAZARI IRAJ | Issue Writer Certificate

Keywords

HYPERTENSIONQ2

L-ARG - ADMAQ1

AEROBIC TRAININGQ1

Abstract

Background and Objective: Endothelial function has an effect on blood pressure and meanwhile, the ratio of L-Arginine/Asymmetric Dimethylarginine (L-Arg/ ADMA) is important. In addition, the effect of exercise training on blood pressure has been established. The present study intends to examine LArg / ADMA ratio in patients with hypertensive middle-aged men and the effect of AEROBIC TRAINING on it.Subjects and Methods: In this quasi-experimental study, 12 normo-tensive and 24 hypertensive middle-aged men (age: 49.66±2.8 y, height: 174.16±4.66 cm, weight: 81.08±12.65 Kg) were selected. The hypertensive subjects were further sub-divided into two groups. 12 for control (age: 52.08±2.53 y, height: 173.75±5.81 cm, weight: 80.08±8.26 Kg) and 12 for AEROBIC TRAINING (age: 50.54±3.01 y, height: 177.01±5.98 cm, weight: 86.09±13.15 Kg). The training included 12 wks treadmill aerobic running with 60 % heart rate reserve, three times-a-week for 12 min each session. each week up to the 6th week 3 min and then every two weeks 3 min were added to the training time. So that training in the last two weeks was 36 min. Blood pressure and samples for the measurement of L-Arg/ADMA ratio were taken before and after the training period. Blood variables were measured by ELISA method. Normality of distribution of data was assessed with the Shapiro-Wilk test and between subjects differences was assessed with independent t-test and analysis of variance with repeated measures.Results: Results showed that the L-Arg/ADMA ratio is more in patients than in healthy subjects (t=5.099, P=0.0001) and sub maximal AEROBIC TRAINING significantly reduced systolic blood pressure (F=8.698, P=0.008) and increased L-Arg /ADMA (F=10.741, P=0.004).Conclusion: It seems that endothelial function in patients with HYPERTENSION is impaired and these patients can do AEROBIC TRAINING to relieve pressure and improve endothelial function.

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APA: Copy

shabaaninia, Maysam, SHAHIDI, FERESHTEH, RAJABI, HAMID, & NAZARI, IRAJ. (2016). A STUDY OF L-ARGININE TO ASYMMETRIC DIMETHYLARGININE RATIO IN MIDDLE AGED HYPERTENSIVE MEN AND EFFECT OF AEROBIC TRAINING ON THIS VARIABLE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 15(6), 745-756. SID. https://sid.ir/paper/12792/en

Vancouver: Copy

shabaaninia Maysam, SHAHIDI FERESHTEH, RAJABI HAMID, NAZARI IRAJ. A STUDY OF L-ARGININE TO ASYMMETRIC DIMETHYLARGININE RATIO IN MIDDLE AGED HYPERTENSIVE MEN AND EFFECT OF AEROBIC TRAINING ON THIS VARIABLE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2016;15(6):745-756. Available from: https://sid.ir/paper/12792/en

IEEE: Copy

Maysam shabaaninia, FERESHTEH SHAHIDI, HAMID RAJABI, and IRAJ NAZARI, “A STUDY OF L-ARGININE TO ASYMMETRIC DIMETHYLARGININE RATIO IN MIDDLE AGED HYPERTENSIVE MEN AND EFFECT OF AEROBIC TRAINING ON THIS VARIABLE,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 15, no. 6, pp. 745–756, 2016, [Online]. Available: https://sid.ir/paper/12792/en

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