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Information Journal Paper

Title

PREVALENCE OF MUTATION IN EXON 2 OF THE BRCA1 GENE AMONG BREAST CANCER PATIENTS AND THEIR HEALTHY RELATIVES IN AHWAZ

Pages

  391-397

Abstract

 Objective: BREAST CANCER is the most common cancer affecting women and 1: 12 of the population will develop BREAST CANCER before the age of 70. Of those, 5 to 10% of these cases develop BREAST CANCER due to autosomal dominant predisposing gene mutation at BRCA1 and BRCA2. The aim of this study was to assess the prevalence of these mutations among BREAST CANCER patients and their relatives in Ahwaz.Subjects and Methods: For this purpose, 38 and 32 blood samples from BREAST CANCER patients and their healthy relatives respectively were tested for possible presence of mutation in exon 3 of the BRCA1 gene using single strand conformational analysis method.Results: the results showed that 10.5% of the patients with BREAST CANCER carried the mutated gene.Conclusion: These results demonstrated that the prevalence of BRCA1 gene mutation in our area is similar to its global pattern.

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    APA: Copy

    GALEHDARI, HAMID, FOROUGHMAND, A.M., RASHIDI GOL ROUYEH, I., ANDASHTI, B., FAROKHI, ALI, FAZELI, GH.R., NEZARI, H., & RASEKH, A.A.R.. (2008). PREVALENCE OF MUTATION IN EXON 2 OF THE BRCA1 GENE AMONG BREAST CANCER PATIENTS AND THEIR HEALTHY RELATIVES IN AHWAZ. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 6(4 (55)), 391-397. SID. https://sid.ir/paper/12843/en

    Vancouver: Copy

    GALEHDARI HAMID, FOROUGHMAND A.M., RASHIDI GOL ROUYEH I., ANDASHTI B., FAROKHI ALI, FAZELI GH.R., NEZARI H., RASEKH A.A.R.. PREVALENCE OF MUTATION IN EXON 2 OF THE BRCA1 GENE AMONG BREAST CANCER PATIENTS AND THEIR HEALTHY RELATIVES IN AHWAZ. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2008;6(4 (55)):391-397. Available from: https://sid.ir/paper/12843/en

    IEEE: Copy

    HAMID GALEHDARI, A.M. FOROUGHMAND, I. RASHIDI GOL ROUYEH, B. ANDASHTI, ALI FAROKHI, GH.R. FAZELI, H. NEZARI, and A.A.R. RASEKH, “PREVALENCE OF MUTATION IN EXON 2 OF THE BRCA1 GENE AMONG BREAST CANCER PATIENTS AND THEIR HEALTHY RELATIVES IN AHWAZ,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 6, no. 4 (55), pp. 391–397, 2008, [Online]. Available: https://sid.ir/paper/12843/en

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