MUTATION DETECTION IN EXONS 3, 10, 12 OF BRCA1 GENE IN 30 PATIENTS AFFECTED WITH FAMILIAL BREAST CANCER

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TEYMOURI H.; MAHDIPOUR P.; ATRI M.; MIRZAI M.R.

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Journal: Journal of Gorgan University of Medical Sciences Year:2002 | Volume:3 | Issue:8 Page(s): 19-24

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Information Journal Paper

Title

MUTATION DETECTION IN EXONS 3, 10, 12 OF BRCA1 GENE IN 30 PATIENTS AFFECTED WITH FAMILIAL BREAST CANCER

Author(s)

TEYMOURI H. | MAHDIPOUR P. | ATRI M. | MIRZAI M.R. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

MUTATIONQ2

BRCA1Q3

PCR-SSCPQ3

Abstract

BREAST CANCER is one of the most common cause of death due to cancer in women. More than half of hereditary breast / ovarian cancer families could be attributed to MUTATION in BREAST CANCER susceptibility gene BRCA1.This study was performed on blood samples of 30 women who affected with familial BREAST CANCER. Non-radioactive PCR-SSCP technique was utilized for MUTATION screening in exons 3, 10, 12 of BRCA1 gene.Two shifts in exon 3 and also two in exon 12 was detected, but no shift in exon 10 was found. Due to low number of recognized MUTATIONs, the statistical analysis didn"t show a meaningful correlation between MUTATIONs and pathological characteristics. Results from this study showed that there was a low possiblity of germline MUTATION in these three exons. Low rate of MUTATION in this report was concordance with the others.

Cites

PENETRANCE ESTIMATION IN BREAST CANCER PATIENTS VIA MODIFIED KIN-COHORT METHOD

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APA: Copy

TEYMOURI, H., MAHDIPOUR, P., ATRI, M., & MIRZAI, M.R.. (2002). MUTATION DETECTION IN EXONS 3, 10, 12 OF BRCA1 GENE IN 30 PATIENTS AFFECTED WITH FAMILIAL BREAST CANCER. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 3(8), 19-24. SID. https://sid.ir/paper/79028/en

Vancouver: Copy

TEYMOURI H., MAHDIPOUR P., ATRI M., MIRZAI M.R.. MUTATION DETECTION IN EXONS 3, 10, 12 OF BRCA1 GENE IN 30 PATIENTS AFFECTED WITH FAMILIAL BREAST CANCER. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;3(8):19-24. Available from: https://sid.ir/paper/79028/en

IEEE: Copy

H. TEYMOURI, P. MAHDIPOUR, M. ATRI, and M.R. MIRZAI, “MUTATION DETECTION IN EXONS 3, 10, 12 OF BRCA1 GENE IN 30 PATIENTS AFFECTED WITH FAMILIAL BREAST CANCER,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 3, no. 8, pp. 19–24, 2002, [Online]. Available: https://sid.ir/paper/79028/en

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