EFFECT OF EXERCISE ON MORPHINE-INDUCED TOXICITY IN RAT LIVER AND KIDNEY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AHMADIZADEH MASSUMEH; SARKAKI ALIREZA; FARBOUD YAGOUB; MOHAMMADIAN BABAK; RAHIM FAKHER

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Jundishapur Scientific Medical Journal Year:2012 | Volume:11 | Issue:3 (78) Page(s): 325-333

Download Full-Text

Persian Verion

View:

2,149

Download:

Cites:

Information Journal Paper

Title

EFFECT OF EXERCISE ON MORPHINE-INDUCED TOXICITY IN RAT LIVER AND KIDNEY

Author(s)

Keywords

EXERCISEQ2

MORPHINEQ3

LIVERQ2

KIDNEYQ2

RATQ2

Abstract

Background and Objective: MORPHINE induces adverse effect in many organs. It has been known that moderate EXERCISE reduces oxidative stress. The present study was undertaken to evaluate the effect of EXERCISE on MORPHINE-produced toxicity in RAT LIVER and KIDNEY.Subjects and Methods: Adult male RATs were randomly divided in 4 groups including: (1) MORPHINE-treated, (2) MORPHINE treated+EXERCISE, (3) vehicle (normal saine) treated, (4) vehicle treated+EXERCISE. Animals in groups of 1 and 2 received MORPHINE (ip) two times per day for 5 consecutive days.1st day 5mg/kg, 2nd day10 mg/kg, 3rd day 20mg/kg, 4th day 40mg/kg and 5th 50mg/kg. RATs in groups of 3 and 4 received vehicle only. The animals in groups of 2 and 4 were participated in the treadmill EXERCISE sessions (1 h at speed 17m/min) for 10 consecutive days.24 h later, the animals were killed with overdose of sodium pentobarbital. Blood was collected for determination of ALT, AST, ALP, BUN and creatinine. LIVER and KIDNEY tissues were removed, fixed and processed for light microscopy. Ten animals were used for each group.Results: Biochemical and histopathological observations indicated that MORPHINE produced injury in the LIVER and the KIDNEY. EXERCISE reduced MORPHINE -induced toxicity (P<0.05).Conclusion: MORPHINE- induced toxicity in RAT LIVER and KIDNEY.Execise protected LIVER and KIDNEY against MORPHINE-induced toxicity. Blocking of oxidative damage by EXERCISE may be a useful strategy for preventing MORPHINE adverse effects.

Cites

No record.

References

No record.

Cite

APA: Copy

AHMADIZADEH, MASSUMEH, SARKAKI, ALIREZA, FARBOUD, YAGOUB, MOHAMMADIAN, BABAK, & RAHIM, FAKHER. (2012). EFFECT OF EXERCISE ON MORPHINE-INDUCED TOXICITY IN RAT LIVER AND KIDNEY. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 11(3 (78)), 325-333. SID. https://sid.ir/paper/12882/en

Vancouver: Copy

AHMADIZADEH MASSUMEH, SARKAKI ALIREZA, FARBOUD YAGOUB, MOHAMMADIAN BABAK, RAHIM FAKHER. EFFECT OF EXERCISE ON MORPHINE-INDUCED TOXICITY IN RAT LIVER AND KIDNEY. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2012;11(3 (78)):325-333. Available from: https://sid.ir/paper/12882/en

IEEE: Copy

MASSUMEH AHMADIZADEH, ALIREZA SARKAKI, YAGOUB FARBOUD, BABAK MOHAMMADIAN, and FAKHER RAHIM, “EFFECT OF EXERCISE ON MORPHINE-INDUCED TOXICITY IN RAT LIVER AND KIDNEY,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 11, no. 3 (78), pp. 325–333, 2012, [Online]. Available: https://sid.ir/paper/12882/en

Related Journal Papers